17-09-2014, 07:44 AM
(17-09-2014, 07:06 AM)Lotus Wrote:(15-09-2014, 04:56 AM)Candace Wrote: Beta sitosterol does inhibit 5-AR, but the content in peony is too low for your reference to specify it, so the effective peony dose would be impractical, and perhaps dangerous if it caused an overdose of the major components.
Oh really, then prove it!
I can imagine you as a pharma rep demanding that the FDA prove that your company's drug isn't safe and effective. I'll play along, though.
Since no concentration is given, we can assume that it's lower than the concentrations that are listed. Let's be generous and call it 0.03% beta sitosterol. Paeoniflorin is 3.3-9.4%. One 600 mg capsule of LEF's extract contains 252 mg paeoniflorin. Assuming that both chemicals are concentrated to the same degree in the extraction process, we would expect to see 0.8-2.3 mg of beta sitosterol in each capsule. The effective dose in the study I cited was 60 mg/day, so 26-75 capsules of peony per day would be required. Impractical!