29-01-2014, 02:17 AM
(28-01-2014, 11:40 PM)Mistress~Lotus Wrote: Scotti,
If you're unsure talk to your doctor, but here's some info regarding phytoestrogens and PM:,
If breast enlargement pills do have estrogen-like effects in the body, there are some safety concerns. Estrogen given on its own stimulates the growth of tissue in the uterus and is believed to promote uterine cancer, which is why birth control pills and hormone replacement therapy normally contain progesterone to counter estrogen's effects on the uterus. We don't know if natural breast enhancement pills stimulate the growth of uterine tissue.
http://altmedicine.about.com/cs/3/a/Herbal_Breast.htm
Estrogens are well known to increase breast cancer risk in some women
http://www.cancer.org/cancer/breastcance...sk-factors
Phytoestrogens, which are widely distributed in plants, are structurally similar to mammalian estrogens and can thus bind weakly to estrogen receptors (1). The 3 major classes of phytoestrogens are isoflavones, which are concentrated in soybeans and soy products but are also found in other legumes; lignans, which are distributed in seeds, whole grains, berries, fruit, vegetables, and nuts; and coumestans, which are found in broccoli and sprouts.
Estrogen is increasingly recognized as a cause of breast cancer. Both elevated concentrations of endogenous estrogen and hormonal therapy with estrogen for menopause are associated with an increased risk of breast cancer (3). However, the role of phytoestrogens is ambiguous.
http://ajcn.nutrition.org/content/79/2/183.full
PHYTOESTROGEN EFFECTS ON BREAST CANCER
Overall, phytoestrogens have a protective effect against breast cancer, though research has shown that in some cases they may induce tumor development. A study in the "Journal of Clinical Oncology" in February 2007 showed phytoestrogens to behave like estrogen when natural estrogen levels are low and unlike estrogen when levels are high. Premenopause, phytoestrogens protect against breast cancer when estrogen levels are high, but promote the growth of cancer cells post-menopause when estrogen levels are low. This study also showed that higher levels of the isoflavone genistein slows the development of tumor cells, protecting against breast cancer.
http://www.livestrong.com/article/517709...n-breasts/
Pm extract-It has been reported that Pueraria mirifica contains estrogenic substance miroestrol, which can be found in the dry rhizome of Pueraria mirifica about 0.002-0.003%. This substance has been proven 2 times more effective than human estrogen.
A series of studies involving breast cell lines and the activity of Pueraria mirifica in vitro have been performed by the Emory University School of Medicine in Atlanta, Georgia, USA, and the Department of Obstetrics and Gynecology, Phramongkutklao College of Medicine, Bangkok, Thailand. These studies have shown that Pueraria mirifica root extract (Smith Naturals Co Ltd., Bangkok) has potent anti-estrogenic properties against aggressive cell cancer lines in vitro, especially the proliferative estrogen receptor-positive (ER+) breast cancer lines (T47-D, MCF-7, and ZR-75-1) obtained from the MD Anderson Cancer Institute (Texas) and the National Cancer Institute (NCI) at the U.S. National Institutes of Health (NIH). Pueraria mirifica promotes fibroblasts in normal breast cells and inhibits estrogen-dependent breast cancer cells. Unpublished, 2001, Sawatsri, S., Juntayanee, B., Jitpatima, S., Boonnao, P., Kampoo, C., Ayuttaya, N., Wongyai, S. and Sidell, N.
LD50 test
On the LD50 test (which measures the dosage that would kill laboratory animals after 14 days, expressed in weight of material per kilogram of body weight), simple water scores a 16. Relative to this, dried PM root scores a more toxic 7-but when the root is administered in the form of a standardized extract, the score raises to 40, causing no animal deaths at all.
Yes, I heard ya!, sorry it took so long!
References? Especially on the LD50. Last time I looked, studies failed to establish an LD50 for PM and that was using dried, powdered root. Also, I was under the impression that there was no such thing as a 'standardized extract' for PM. So, love to get a link to that one.
Thanks.