None of them, in any combination it seems, gave me any noticeable results. Definitely not the results I see some of the members here have gotten. After seeing an endocrinologist, I was given Rxs for estrogen, prometrium and Spiro. I was on that regimen for many years, in one form or another, until I had to stop because of an unrelated medical issue. After being off hrt for a couple years I started using an estrogen gel and progesterone cream 5 months ago. My breasts were saggy and had lost any fullness, but after a couple months I started seeing some fullness coming back. The effect on my nipples has been even more pronounced. I'll post a couple pics in the photo section today.
M