The thing about creams that's a hot topic here right now is DHEA and progesterone along with tiny drop of estrogel (estradiol) to go with it, also Lotus talked about adding topical anto androgen into it, but so far I've done only DHEA + PG + E2 and had fantastic success with it. Then again, DHEA is adaptogen and can do a whole lot, how would it react on cis fem hormone balance especially for one who has PCOS? This is a question I don't know answer to. What I do know that for me this combination has been amazing.
Before it I also did estriol cream on its own for a month and that too seemed helpful. I could see how combining estriol and estradiol topically could be helpful as elevated local estrogens in breast tissue is one of the things that can help grow a lot. (One of the things noted many women diagnosed with macromastia have along with list of other things.)
I think the topical route is really awesome idea and worth doing, just keep dosages moderate and it should work out fine. I can't say much about cycling it as I don't cycle stuff, my body is so weird it does that on its own do I want it or not.