11-03-2015, 12:41 AM
(11-03-2015, 12:20 AM)spanky Wrote: I wish the study discussed in this abstract were available. If it is I cannot find it.
http://ict.sagepub.com/content/2/2/120.short
This PDF is working:
Hops (Humulus lupulus) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A)
http://cancerpreventionresearch.aacrjour...3.full.pdf
Long-term exposure to estrogen resulting from a combination of early onset of menstruation, nulliparity or delayed first child birth, short duration of breast feeding, late menopause, and use of hormone replacement therapy (HRT; refs. 1, 2) increases the risk of hormone-dependent cancers in women (3, 4). Two major mechanisms for estrogen carcinogenesis have been proposed which include estrogen induced cell proliferation in estrogen receptor (ER) positive cells (hormonal pathway) and the formation of reactive estrogen metabolites (chemical pathway, Fig. 1; ref. 5). Understanding these mechanisms can lead to strategies for prevention of estrogen-dependent cancers which can enhance the quality of life for women as well as significantly reduce the cost of health care.