06-04-2014, 10:14 AM
(05-04-2014, 08:36 PM)~Lotus~ Wrote:(05-04-2014, 11:15 AM)spanky Wrote:(04-04-2014, 06:59 PM)~Lotus~ Wrote:(03-04-2014, 11:52 PM)myboobs Wrote: Actually I spray it on back of tounge and swallow itthan wash it down with my tincture mixture
If you want the biggest bang, go for under the tongue, just a drop or two at first. Try it 2-3x daily until you can manage the taste and then increase the amount as you can tolerate.
Sublingual
Certain drugs are best given beneath the tongue or retained in the cheek pouch and are absorbed from these regions into the local circulation. These vascular areas are ideal for lipid-soluble drugs that would be metabolized in the gut or liver, since the blood vessels in the mouth bypass the liver (do not undergo first pass liver metabolism), and drain directly into the systemic circulation. This route is usually reserved for nitrates and certain hormones.
Only let it absorb for a few minutes, and then wash it down.
Would it be better to take all of the extracts this way, such as white peony root? How can you tell if something is lipid-soluble?
Hi spanky,
I would think so, opinions will vary based upon preference imo. I was never into taking anything sublingually. Give me a shot or a pill, lol. But after months or even years perhaps of the most common route (orally) which now has led me to believe its worth experimenting. What's your opinion?
LIPID SOLUBILITY -the ability to dissolve through the lipid (fat) portion of a membrane; steroids and other lipid-based molecules, for example, pass through membranes easily and are said to be "highly lipid soluble"
DIFFUSION -movement of solute particles from an area of high concentration to an area of low solute concentration; solutes are said to diffuse "down their concentration gradient
SUBLINGUAL -certain drugs are best given beneath the tongue or retained in the cheek pouch and are absorbed from these regions into the local circulation. These vascular areas are ideal for lipid-soluble drugs that would be metabolized in the gut or liver, since the blood vessels in the mouth bypass the liver (do not undergo first pass liver metabolism), and drain directly into the systemic circulation. This route is usually reserved for nitrates and certain hormones.
ORALLY -by far the most common route. The passage of drug from the gut into the blood is influenced by biologic and physicochemical factors and by the dosage form. For most drugs, two- to five-fold differences in the rate or extent of gastrointestinal absorption can occur, depending on the dosage form. These two characteristics, rate and completeness of absorption, comprise bioavailability. Generally, the bioavailability of oral drugs follows the order: solution > suspension > capsule > tablet > coated tablet.
TOPICALLY -a topical medication is a medication that is applied to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including but not limited to creams, foams, gels, lotions and ointments.
Thanks for the detailed reply. When I purchase some extract, I will try it sublingually. If I had not already overstocked with PM powder, I would try the extract of that as well.
