Search function. Read the topics about topical protocol, there's a specific thread about it which Lotus posted not long ago, your're posting in it, there's more information in her project X thread and I'm doing my own twist on the same program which I talk about a lot in my thread.
So far the topicals we're talking about seem to work very efficiently and safely, all ingredients to it are quite easy to get excluding progesterone capsules and estrogel which are typically behind prescription wall, unless you know how to cirmucvent medical gatekeeping which I wont discuss in much detail on BN.
Cycling might have some benefits to a cis woman or anyone with functioning ovaries, but most likely men and trans women do not need to cycle things. I do it on progesterone as a way to save some money as stocking up on grey market medication is expensive. Also I'm a bit of an outlier as I'm very likely intersex and I have very obvious monthly cycle which causes plethora of symptoms which can only happen when there's fully or partially functional female body parts inside. So I might benefit a bit more from cycling some HRT/NBE items, but most of the time its unnecessary.
I have been on the topical protocol without much breaks for fourteen months, zero side effects of health problems so far. I've kept the main pieces of the program as outlines in this thread, I've added some ingredients and tweaked dosages, but mainly its the very same protocol in its core. Lotus was on it for quite long time, Stevenator is doing it biweekly at the moment and there are few others here who have dabbled with it already. So far nobody has reported any adverse effects and it seems to be very efficient to the point of being a game changing discovery. Note that there are studies linked on the forum on which all this is based upon. Its not like this was invented out of thin air.
I will soonish update about latest experiement with red clover on the side and there's something neat which hasn't even been talked about much yet on this, so more information will be coming. ^_^