I spent months studying the subject and am currently undergoing HRT supervised by Dr. Powers.

As far as I can see (corroborated by Dr. Powers):

1. Local E2, in addition to E2 HRT, makes sense, but levels should be checked since even some OTC E2 creams are high concentration.
   
2. Success stories are from people who are on E2 HRT protocols as well. That should disqualify such evidence since E2 is a key component in breast development.
   
3. Protocol specifics are made from short periods of self-observations of a single person with multiple changes simultaneously. 
   
4. Universal DHEA suggestion is problematic:
   a) for an unknown share of users, it would generate more androgens than estrogens (that's what it does for me)
   b) with topical E2, it's a moot point to generate more E2 locally - oversaturation of receptors is not helpful
   c) it can also have progestogenic effects, which should be avoided in early development.
   
   

Ernie, I'm a Powers patient too. I do agree topical creams can achieve female levels. Dr. Powers has an E2 topical formula that's made in a compound pharmacy and it's formulated at 10% E2 and 10% DMSO… the stuff works excellent. It's pricey though. I use it on my breasts. I also use Prometrium (Prescription required) capsules (aka- P4) on my breasts, as well as topical DHEA OTC cream. Which is proven (w/scientific studies) to help reduce breast atrophy. The science is listed on page one. Additionally listed is my evidence of success.

I disagree with some of your comments listed above, which is okay to disagree.  Lara has taken her own path, her success seems to be a hot bed for others to offer commemts or opinions on when they don't have her kind of success. Sure, Lara gets heated up by negative comments, I would too. I not perfect myself, but I have learned (after being here for over decade to chill first before blasting others). 

 Dr. Powers is aware of my statements (made many years ago) on the potential of PPAR-y agonists. From my experience using the latter it has greatly influenced the bottom half (to female form) of my bottom. I've attached a picture in the X-thread. Also in the X-thread I've shared lab results when I used the topical cream protocol… which some have already forgotten about. Here's the link:

Test Results
https://www.breastnexum.com/showthread.php?tid=17436&page=501

Additionally:

Bigger nipples
https://www.breastnexum.com/showthread.php?tid=17436&page=491

Dr. Powers is truly an amazing person and Clinician/Scientist/Trail Blazer and treats folks with compassion and understanding. Dr.Powers and his PA Sommer saved my life by diagnosing my Leukemia, they picked up on my abnormal blood levels when other doctors didn't. My programs and knowledge stem from following Dr. Powers methods. Though I've tested alternative methods on myself (safely) throughout the years… my breasts are the healthiest part of me. I've shared that information in the X-thread. It's unfortunate that Lara and yourself muddied this thread, and the content will be removed.

Here's a quote I saw on reddit that should resonate for new and old members at nexum. It's not directed at any one person. Food for thought though. 

“I have very limited chill for people who wander in, start new threads, and can't be bothered to type more than 8 words or show any evidence they tried to answer their own question. It's inconsiderate to the people who hang out here and try to provide high quality, scientifically validated medical advice for free.”

Hey Lotus. Thanks for coming in with calm responses. For starters I have collected all of your messages on X thread and extracted structured statements and links that I use with chatgpt o1 pro to analyze them and get additional reasoning and data. Don't be distracted by my low post count.

I have a few questions;

1. I have a feeling that your cream is not 10% of E2, but 10% of 0.06% gel. Because otherwise 1g of cream would be 100mg of topical E2 that would yield insane local blood levels. Am I right?

2. DHEA efficiency looks to be very dependent on genetics and in my case it produces tons of local androgen. Do you agree that in such case it should be avoided?

3. Am I right that you believe that RC is the most effective PPAR-Y agonist? And if so, how do we know it's not competing for receptors with e2?

Thank you

I disagree with some of your comments listed above, which is okay to disagree.  Lara has taken her own path, her success seems to be a hot bed for others to offer commemts or opinions on when they don't have her kind of success. Sure, Lara gets heated up by negative comments, I would too. I not perfect myself, but I have learned (after being here for over decade to chill first before blasting others). 

 Dr. Powers is aware of my statements (made many years ago) on the potential of PPAR-y agonists. From my experience using the latter it has greatly influenced the bottom half (to female form) of my bottom. I've attached a picture in the X-thread. Also in the X-thread I've shared lab results when I used the topical cream protocol… which some have already forgotten about. Here's the link:


Here's a quote I saw on reddit that should resonate for new and old members at nexum. It's not directed at any one person. Food for thought though. 

“I have very limited chill for people who wander in, start new threads, and can't be bothered to type more than 8 words or show any evidence they tried to answer their own question. It's inconsiderate to the people who hang out here and try to provide high quality, scientifically validated medical advice for free.”

I have noted a pattern, each time I have made some sort of a leap or a breakthrough with results and finding new ways to enhance NBE, someone gets a hissy fit over it.

I want to comment on the PPAR-y side of things, and using TCP mixture on lower body, its having a profound effect! I've been doing this for quite some time now and the difference is glaringly obvious, my picture updates clearly show this change. Also the effect of Volufiline and RC extract appear to slowly add up, just as discussed earlier. Obviously neither Volu or RC comes close to what Pioglitazone can do, but Pio seems to slow down or stall breast tissue development so that should be another layer of caution on its use.

The test of 25mg oral DHEA seems to be working well, it appears that 50mg Bica per week is enough to keep androgen issue under control and I seem to be getting only benefits from it. Testing it while on Cypro didn't give same results, but that was also done on higher dosing. Also I notice obvious quickening of fat distribution change during previous month. This I think is something deserving a deeper look. 


I like that quote.

A call for calm please on this and other threads.
This is a wonderful place to be, really supportive and friendly so please lets keep it that way, thank you all for being here.

Enough said on that, back on topic.... I'm focused on lower half feminisation so really interested in the lower half topical regime and PARR-y.

From my limited experience with my TCP adaptation it does seem to be a bit of a game changer, it's like it's own little sub-topic of TCP  

Currently doing my TCP daily at night:

Mix together - DHEA (75mg), Ovarian Glandular (250mg), Multi-glandular(450mg), 3xpumps of Prog cream (alt day Oestrogel) and a dropper full of RC extract.

Application:
- spray disinfect upper leg thighs, buttocks, scrotum and areolas and let it dry
- slap mixture on and rub in
- add 1 dropper full of cayenne extract to each thigh and rub that it in
- slap on some aloe vera gel

Most of the mix goes on my lower half, a small amount onto my areolas and any left over goes on my scrotum.  

I also dermaroll the application areas once a week, I did intend to do it more but decided to stick with once a week.

I'm loving it and all intel etc is greatly appreciated, thanks.

 I'm focused on lower half feminisation so really interested in the lower half topical regime and PARR-y.

From my limited experience with my TCP adaptation it does seem to be a bit of a game changer, it's like it's own little sub-topic of TCP  

Currently doing my TCP daily at night:

Mix together - DHEA (75mg), Ovarian Glandular (250mg), Multi-glandular(450mg), 3xpumps of Prog cream (alt day Oestrogel) 

Take into account that it's impossible to distinguish effect of topical PPAR-y agonists from a regular trans-HRT fat redistribution. 

Also, estrogel every 2 days is not recommended - it makes large estrogen waves with potential mood swings, hot flashes etc. Gel based suggested twice a day, cream based - daily.

Except when there's frequent measurements and pictures documenting the changes day by day. It is quite easy to distinguish program changes with a decent diary + pictures and measuring tape. Especially apparent with Pioglitazone, volufiline and RC extract are more subtle.

Has anyone doing the every other day prog/e2 method experienced crazy mood swings and hot flashes?

EDIT:
Just FIY, as Lotus cannot be around all the time due to her health problems, I feel its up to me to keep helping out and answering questions when I can. I'm absolutely sick of internet stupidity and I'm not running on full steam myself either, but I'll try. This thread and none of the main ones will be turned into garbled mess by Reddit tourists.

 I'm focused on lower half feminisation so really interested in the lower half topical regime and PARR-y.

From my limited experience with my TCP adaptation it does seem to be a bit of a game changer, it's like it's own little sub-topic of TCP  

Currently doing my TCP daily at night:

Mix together - DHEA (75mg), Ovarian Glandular (250mg), Multi-glandular(450mg), 3xpumps of Prog cream (alt day Oestrogel) 

Take into account that it's impossible to distinguish effect of topical PPAR-y agonists from a regular trans-HRT fat redistribution. 

Also, estrogel every 2 days is not recommended - it makes large estrogen waves with potential mood swings, hot flashes etc. Gel based suggested twice a day, cream based - daily.

Overall I'm seeing my lower half feminise more than ever, agreed though, it might just be regular trans-HRT fat redistribution, but the rate of change has certainly increased since adding my topical regime.

I'm using gel and so far, not had any mood swings, hot flushes or other side effects, but will keep a close eye on it and thanks for the heads up.

Hello lovely BN friends. 

You might have been wondering where I have been as I've been very inactive lately. I'll update right now, I've been doing the grind, carrying on and keeping calm, going through the motions. I'm still waiting more news on my coming surgery and I've been doing absolutely maxed out TCP and maxed out NBE and gaining weight as much as possible as an asset gathering and squeezing everything out of TCP as what is possible as more I grow now, more room there is for the coming fat transfer.

I have observations to discuss in detail, Lotus' findings keep being proven to work, as is our combined effort on topicals. My ideas with boosting absorbtion and HGF levels seemt to work amazingly well on top of the basis of the program and I have added an extra step to physical stimulation. I've been going to sauna more frequently to help heal ezcema which is working fine, but then I've started to brush my breasts using quite rough brush and very hot water to do it, not hot enough to cause burns, but as much as I handle. It is established fact that heat can help breast development, it might also help with heparin release which deals with HGF levels, it excites blood circulation and brushing with very hot water helps to exfoliate dead skin which speeds up recovery from dermarolling and allows easier absorbtion of TCP ingredients.

I've been doing this along the usual program for about two months now twice or more each week. I have also added Caynne extract with Bovine Ovary back as it wasn't the cause of ezcema flares, I'm doing prog and estradiol on alternating days which is fantastic idea and I've been slowly gaining weight which keeps on hitting the right spots! I'm convinced by now that TCP ingredients are indeed elevating local PPAR-y activation and thus helping fat cell division in said areas.

Here's couple of quick snaps from a week ago. I think the pictures speak for themselves.


Sitting in bad posture and leaning forward a bit and my nipples are almost reaching my belly button. Achievement unlocked much?  Anyway, TCP + controlled weight gain are amazing, every day I keep going is proving Lotus' findings correct. I so much want her to be able to come online and see how amazing this is.

I hope I'll have reason and chance to do a longer update on my thread in coming days, with more pics and information to share. I'll post updated program details too once I get to it.

Was wondering if you were OK as you have been absent for a while glad  you are back. Your boobs are so big and areola and nipples are fantastic. Yep your boobs  touch your belly button 

Remember when Lotus talked about RC extract doing wonders on areolas and nipples? I've been applying both Cayenne extract and RC extract on areaolas and immeidately around them lately. Less mess and smaller doses are enough and its working well. Also worth noting is that I've had obvious quickening of changes in last three months and that's the time I've been doing a nightly EVOL shot along with topicals and every other day progesterone.

I will make a detailed post in my thread soon as there's more to talk about than TCP alone, even though its probably the main culprit of my body changes lately. Its been repeatedly called a game changer and for a good reason. There's more to talk about though as the changes are a combined effect of several things. Bica I'm sure has been very beneficial too. Anyway, more about everything else later, I'm going to try to take new timeline pictures and get something tangible about the surgery dates down before it.