[Lotus]

I've been trying to find the composition of PM to estriol and came across the first web site, and wow!, I don't think I've found anything as complete and scientific review than this. Even if you don't understand the science you'll get a better understanding of PM, Btw dexymiroestriol is stronger than miroestriol for those who don't know.

In lay terms, the ingredients in PM are similar to estradiol, which attach itself to your estrogen receptors and prevents the more serious "real estrogen"from proliferation of breast cells and potentially becoming cancerous!. It's not all fun and games though, E dominance can occur, progesterone is then suggested to balance it out.


Reading below will make your eyes bleed, or give you a F**kin migraine, read at your own risk!

Miroestriol (the bioactive component of Pueraria Mirifica) appears to be a quarter as
potent as 17β-estradiol in inducing estrogenic like effects.
http://examine.com/supplements/Pueraria+mirifica/

Pueraria Candollei var. Mirifica (Kwao Krua) appears to have a large amount of phytoestrogenic compounds, particularly isoflavones, including the ones known as Soy Isoflavones; there is also a class of three molecules known as chromenes, and the molecules in this class (Miroestrol, Isomiroestrol, and Deoxymiroestrol) are estrogenic with a similar potency to estrogen itself.



Only PM has the unique phytoestrogen (plant estrogen), miroestrol. Miroestrol is bio-similar to estriol, an estrogen (female hormone) that is much weaker than the body’s predominant estrogen, 17ß- estradiol. Miroestrol occupies the estrogen receptors more safely. If the estrogen level is high, miroestrol will compete with receptors weakening the effect of the hormones. If the estrogen level is low, miroestrol will exert its estrogenic effect of potentiation. PM also contains several other phytoestrogens including genistein, daidzein, hydroxymiroestrol and isomiroestrol.



The standardized powdered extract is adjusted to comply with the adjusted product specification which is identical to the concentrations of the liquid extract product. Preferably, each 100 g of the powdered extract contains ≧20 mg miroestrol (deoxymiroestrol), about 3-11 mg daidzin; about 12-30 mg puerarin; about 0.5-2 mg genistin; about 1.1-3 mg daidzein; and about 0.2-2 genistein. The recommended dose of the product for internal use is 80 mg of the extract 1 to 2 times/day.

The stability of the constituents was monitored by HPLC before and after spray-drying. No decomposition or degradation could be noticed (neither new peaks, nor disappearance nor reduction of any peak, nor the appearance of new shoulders). This provides reasonable assurance that a constituent, standardized and effective product is produced. Toxicity tests using a mutagenicity assay have shown the extract is negative for Staphylococcus Aureus, Salmonella typhimurium and E. coli.




The structure of miroestrol is not a steroidal hormone but is a 21 carbon compound with a 6-membered ring instead of the 5-membered ring of estradiol-17β. The similarity between miroestrol and estradiol-17β is in the size of the 4-ring molecule. The aromatic ring with the phenolic hydroxyl group at position 3 are present in miroestrol and estradiol-17β. The β-hydroxyl group at position 18 in miroestrol corresponds to the 17β-hydroxyl group of estradiol-17β and the β-hydroxyl group in the 17 position of estriol. The 17α-hydroxyl group of miroestrol corresponds to the 16α-hydroxyl group of estriol. Miroestrol is a unique phytoestrogen that is very similar to estriol while being non-hormonal and non-steroidal.

http://www.freepatentsonline.com/7658955.html