31-01-2014, 08:48 PM
How many have thought that facial hair was a sign of too much Testosterone?.....guilty! (me), so I'd suppress more and more to the point it was non-exist. not good!
DHT should be our enemy for breast growth-
How does DHT protect against estrogen? There are at least three ways that this likely occurs. First of all, DHT directly inhibits estrogens activity on tissues. It either does this by acting as a competitive antagonist to the estrogen receptor or by decreasing estrogen-induced RNA transcription at a point subsequent to estrogen receptor binding.
See the paragraph-Anti-Estrogen effects of DHT
http://www.bodybuilding.com/fun/reform8.htm
Now let's talk about this as it relates:
Testosterone has two metabolites that pose potential problems for aging males and also for bodybuilders and athletes. One is estradiol (testosterone is converted to estradiol by the enzyme aromatase) and the other is dihydrotestosterone (DHT) (testosterone is converted to DHT by the enzyme 5-alpha reductase). As men age, there is a dramatic decrease in testosterone production, but without a corresponding decrease in the production of estradiol and DHT. Even though testosterone levels have plummeted, the aromatization of testosterone to estradiol is maintained, or even accelerated, and more testosterone is also being aromatized in fatty tissues. This creates excess levels of estradiol and, as a consequence, a blood level ratio of testosterone to estradiol that continues to decline, tipping the scale in balance of an estradiol-dominant environment.
Next post we'll try to tie all this into a nice bow for ya!
Quote:I know that DHT (dihydrotestosterone) comes after testosterone (T) is catalyzed by 5-alpha-reductase. Both T and DHT has SIMILAR receptor, but DHT fits more properly to the receptor rather than T, thus it is said that DHT is "activated" T.http://www.biology-online.org/biology-fo...t8648.html
However, from their function, it is stated that they have specific targets, for instance that DHT mainly affects on skin and genital (externa), while T mainly affects in spermatogenesis, spermatozoa maturation/capasitation, responsible in the appearance of secondary sex characteristics (virilisation) and anabolic effects.
DHT should be our enemy for breast growth-
How does DHT protect against estrogen? There are at least three ways that this likely occurs. First of all, DHT directly inhibits estrogens activity on tissues. It either does this by acting as a competitive antagonist to the estrogen receptor or by decreasing estrogen-induced RNA transcription at a point subsequent to estrogen receptor binding.
See the paragraph-Anti-Estrogen effects of DHT
http://www.bodybuilding.com/fun/reform8.htm
Now let's talk about this as it relates:
(22-07-2013, 12:56 PM)AbiDrew85 Wrote:(22-07-2013, 07:58 AM)gogirlanime Wrote: SHBG? Could someone please explain what that is and what you are talking about in more depth, I can sort of figure it out but I think I am having the same problem but don't understand it.
SHBG is sex hormone binding globulin. It's primary purpose is to make excessive sex hormones inert, and it's order of preference is free testosterone, dihydrotestosterone, estradiol, estriol, estrone. Doesn't even touch progestins. Instead your body generally attempts to break excess progesterone down into other hormones, depending on what the balance is... If you introduce excessive progestins to your body, which do NOT break down, well, that's part of why progestins are nasty buggers.
What they WERE talking about was really quite fascinating science. You do realize you necroposted to a nigh two year old thread, right?
(21-12-2011, 08:35 PM)Isabelle Wrote: Hi mochaccino,
If your programs depends on aromatase to make estrogens from testosterone, lowering SHBG is useful. SHBG binds free testosterone, which makes it inaccessible for aromatase.
SHBG binds DHT too, so you'll break out if SHBG becomes too low. Use flax to increase SHBG. Eve M used about equal amounts of flax and oats.
Testosterone has two metabolites that pose potential problems for aging males and also for bodybuilders and athletes. One is estradiol (testosterone is converted to estradiol by the enzyme aromatase) and the other is dihydrotestosterone (DHT) (testosterone is converted to DHT by the enzyme 5-alpha reductase). As men age, there is a dramatic decrease in testosterone production, but without a corresponding decrease in the production of estradiol and DHT. Even though testosterone levels have plummeted, the aromatization of testosterone to estradiol is maintained, or even accelerated, and more testosterone is also being aromatized in fatty tissues. This creates excess levels of estradiol and, as a consequence, a blood level ratio of testosterone to estradiol that continues to decline, tipping the scale in balance of an estradiol-dominant environment.
Next post we'll try to tie all this into a nice bow for ya!