[AnnieBL]

I have been taking all my PM in one dose for some time, in my case 3.75gm per day most of the time, but I take it in the morning before breakfast. No ill effects - I do get back ache in the morning but I think it is just the inevitable arthritis. In my next cycle I may try taking it last thing at night instead and see if it makes any difference. Also I should if taking it in the morning probably take it immediately on waking rather than waiting 90 minutes or so to match the pattern of natural female estrogen levels more closely.