[AnnieBL]

The various recent references to PM producing insulin responses have made me sit up and take notice. I have been taking my entire daily PM dosage shortly before breakfast - indeed since I take the powder with yogurt it is really part of my breakfast. Although my fasting glucose levels and A1C are well within the normal range without medication, I do seem to have impaired glucose tolerance. Certainly I have suffered substantial diabetic type peripheral neuropathy, something to which poor circulation in my legs and hands may have contributed. I try to limit glycemic load in my meals, but in the interests of avoiding stress to marital relationships, they certainly tend to contain some sugars and rapidly assimilated carbohydrates. I have noticed that the blood pressure meds that I also take before breakfast sometimes but not usually result in a precipitous but fairly short term drop in blood pressure (this happened even more so before I was taking PM), combined on occasion (for example when I had to miss breakfast to catch a plane) with hypoglycemic symptoms. Does this represent a problem with my PM dosage timing?

My apologies to Akai Sin if I seem to be hijacking your thread, but dose timing was part of your query, and the insulin response issues emerged in the replies.