[EricaB]

I've read that fat cells prefer to shrink, emptying themselves of their fat content. But once you've lost a really large amount of weight, the fat cells will disappear. So will muscle cells under those circumstances.

Just look at photos of any person who was in a World War II concentration camp or any person with an eating disorder such as anorexia; they're mostly skin and bone with no fat and almost no muscle.

As a side note, if the person is female, almost all of their breast tissue is gone also.