[Pansy-Mae]

I can't help with the brain stuff, but although I'm an advocate of cycling, I don't think its a good idea to have a week completely off. Women never stop producing E so why would we want to? Plus, a week is enough for me to start to lose fat deposits and volume, and it takes longer to replace than to lose it, so a week completely off is a definite negative, for me.
I'd suggest dropping to 2 x500mg or even 1 x500mg for a few days ( 2 or 4), before going back up.