(08-03-2013, 08:23 PM)moniker Wrote: can't find the supporting documents at the moment, but when consuming estradiol orally, 90% of it gets excreted via liver metabolism and that which remains is predominately converted into estrone. Sublingual absorption and injection, however, puts the goodies straight into the bloodstream.
I'm not sure how it works with PM, since it's different stuff and, while it can bind to estrogen receptors, we probably don't have the enzymes to metabolize it, so it probably doesn't get downgraded (though much will be lost in the liver or denatured through the digestive process).
Yes, the liver metabolism of estradiol is well known.
However you are right that PM is different and in fact it works BETTER for being processed by the liver. PM contains miroestrol which the liver converts to de-oxymiroestrol which is significantly more effective.
There is a scientific paper on this which I've read but also can't find atm.
However on the subject of making tinctures, why bother buying a powder and going through all the hassle of extracting? Why not just buy the liquid extract from the same company that you would buy the powder from? Their controlled lab extraction is going to be far more effective than your kitchen ( unless you do have lab facilities, in which case I apologise!)