Personally I've never found any problem with taking PM just as I go to bed. I can't say I've specifically noticed the other effects but I would say that sometimes I wake up in the wee small hours bathed in sweat ( hot flashes?? 
) and the boobs always look bigger when I first get up than later on, which I've always attributed to drooping due to lack of support when I'm at work.
) and the boobs always look bigger when I first get up than later on, which I've always attributed to drooping due to lack of support when I'm at work.