(20-02-2013, 01:21 AM)AnnabelP Wrote: it still leaves the question of whether growth is more dependent on high average estrogen levels or high peak levels. Given that estrogen levels in genetic females appear to have wide diurnal and monthly variations, the latter strikes me as more likely.
There may be some empirical support for the 'peak' theory.
1) I certainly found that when varying my dose on a monthly cycle basis, I noticed increased growing pains on both sides of the peak intake.
2) Quite a few people have commented on an apparent short duration spurt in growth after they have completely stopped taking PM.
Personally I have attributed both those effects to the body being sensitive to changes in levels, not the actual level itself, that could also tie in with peak although in a lightly different mechanism.