06-01-2013, 05:22 AM
An Interesting Part of it (emphasis Added)
This would Suggest that GID could be more of a Genetic Disorder/Mutation, also it Implies that DMRT1 can be "converted" into Foxl2 and vice versa, perhaps the same applies for Chromosomes as well?.
Quote:For the genetic research community this new understanding is a breakthrough. The findings provide new insight into how to turn one cell type into another, a process known as reprogramming, and also show that throughout life, cells in the testis must be actively prevented from transforming into female cells normally found in the ovary.
"This work shows that sex determination in mammals can be surprisingly prone to change, and must be actively maintained throughout an organism's lifetime," said Dr. Susan Haynes, who oversees developmental biology grants at the National Institute of General Medical Sciences of the National Institutes of Health. "These new insights have important implications for our understanding of how to reprogram cells to take on different identities, and may shed light on the origin of some human sex reversal disorders."
The new findings may force the scientific community to reconsider how disorders involving human sex-reversal occur. Some of these disorders may not result from errors in the original sex determination decision in the embryo, but instead may result from failure to maintain that decision later in embryonic development. In addition, because DMRT1 has been associated with human gonadal cancers, the researchers hope their findings will provide another clue into how gonadal cancer develops.
This would Suggest that GID could be more of a Genetic Disorder/Mutation, also it Implies that DMRT1 can be "converted" into Foxl2 and vice versa, perhaps the same applies for Chromosomes as well?.

