(15-11-2012, 09:36 PM)JTX Wrote: AD,

I've been looking over your charts and graphs on page 10. Besides wondering why you are going to use the EV, I have some observations concerning the PC and your purposed plan.

1. The PC I bought recommends 2-4 1/4 tsp doses each day for 21 days on and seven days off. Each 1/4 tsp has approx. 22 mg of Progesterone in the cream I purchased. By that gauge, your dosage peaking at four 1/4 tsps during the middle of your "follicular" stage seems rather conservative.

2. The PC's recommended dosage is about 84 tsps each month. Your initial goal appears to be about 1/3 of that.

3. Because the PC's directions also said that the doses could be increased as required, higher dosages for short durations, to mimic a female's natural system, should be fine.

4. Plot this progression on a chart to compare against yours and please let me know what you think.

Day......PM Caps.......PC 1/4 tsp
1..............2...................0
2..............2...................0
3..............3...................0
4..............2...................0
5..............2...................0
6..............2...................0
7..............3...................0
8..............4...................0
9..............5...................0
10............6...................0
11............7...................0
12............8...................1
13............8...................1
14............7...................1
15............5...................3
16............4...................4
17............3...................6
18............4...................8
19............5...................9
20............6...................9
21............5...................9
22............4...................8
23............3...................7
24............2...................5
25............2...................3
26............2...................1
27............2...................1
28............2...................0

The PM caps are Ainterol's 500 mg caps, as opposed to your drops, a 2:1 difference.

Just curious to your thoughts about my observations.

JTX

I dunno about your body, but I'm already almost certain I'm already towards the high end of a male progesterone level, which would mean between 10-15 mg is circulating in my blood supply naturally. Also it does appear I was not entirely clear in my wording, but once I add the EV I -will- be taking it twice a day. If I were to take 1/2 tsp in a day I'll be adding roughly 41 to 42 mg bringing me to somewhere in the neighborhood of 51-57 mg of progesterone in my entire bloodstream. When taken in the context given just now, that's really a LOT of progesterone. Especially when you consider the "staying" power of PC in the body after it is applied. You could extrapolate that my intended absolute peak progesterone level is likely in the neighborhood of 65 mg.

The recommended dosing on the label of PC creams are intended for post menopausal women, whose P levels can sometimes be even lower than the lower end of male P levels. IE - undetectable. At their suggested dosage, you're basically completely replacing a non-existant progesterone supply.

So yes, I am planning on taking far less progesterone than is suggested on the label.

As to why I'm planning to take EV - I feel the need for more than one type of estrogen for my purposes. I'm a transsexual who is looking to feminize herself as completely as is possible. Thus flooding all my E and P receptors is the ultimate goal of my supplementation. Just using PM cannot flood all receptors, ultimately, no matter how much PM you take, it will fail to bind to some alpha receptors. Human estradiol, whether natural or synthesized by a lab from diosgenin, will mop up those remaining receptors and the combination should provide me with the most complete flood possible.

Progesterone is a different beast entirely. I really don't want to risk flooding any of my P receptors with any known progestins. They're all of them toxic in some way or another. But at a peak of 65mg, I'll be doing a pretty good number on them, and since it's all USP - equivalent to naturally produced human progesterone - the risks are minimal.

EDIT: BTW... Everything I just said I said without bothering to plug your numbers in a chart. I really didn't need to. Your PC numbers are likely needlessly high unless you have a naturally low progesterone production. As for the PM... I'm really not completely certain that the pills and drops are so easily compared in potency. The liquid extract is precisely extracted and I know EXACTLY how much deoxy and miroestrol I'm getting from it. The pills are not standardized and could contain a range of amounts of the powerful estrols compared to other constituents.