As for why it'd be more effective to hit both kinds of receptor... that's going to only be true for people seriously short on estrogens naturally. Most women have plenty of estradiol freed up by the saturation of their beta's by phyto's to bind to the alpha's.

Genetically male individuals on the other hand, generally have no natural estrogen to speak of, and as part of their androgen blocking will often block off what little estrogen they did produce naturally, at least, if they're trying to go for full fem.

For them, they have nothing to hit those alpha's at all if ALL they use are phyto's.

Soooo... I'm using BO in hopes of hitting my alpha's with animal estrogens while the PM goes to work on the beta's.

Why is it important to saturate both receptors to the best of your abilities? I'd think that should be pretty obvious - we're trying to emulate early puberty here. Tell our bodies it's still time to grow. What happens during early puberty? We're absolutely flooded with hormones. Which hit both receptors.

At least, that's what I'M trying to do...