[Manue]

Thank you, HN, for the leads and attachments. After a first pass through the material, I’m trying to map where BO would add something beyond a well-tuned baseline. For someone already on an optimized HRT setup (E2 on the higher end of range, progesterone appropriately dosed/used, and testosterone suppressed into typical female ranges), BO may have limited incremental impact. A lot of what’s described also overlaps with things that can shift from fundamentals like nutrition, energy balance, and time.

That said, I agree the response seems highly individual and hard to predict. I’ll read the documents more carefully, but at the moment I’m leaning toward “maybe redundant if HRT and diet are already dialed in,” rather than a universal multiplier.