[Ernie]

I spent months studying the subject and am currently undergoing HRT supervised by Dr. Powers.

As far as I can see (corroborated by Dr. Powers):

1. Local E2, in addition to E2 HRT, makes sense, but levels should be checked since even some OTC E2 creams are high concentration.
   
2. Success stories are from people who are on E2 HRT protocols as well. That should disqualify such evidence since E2 is a key component in breast development.
   
3. Protocol specifics are made from short periods of self-observations of a single person with multiple changes simultaneously. 
   
4. Universal DHEA suggestion is problematic:
   a) for an unknown share of users, it would generate more androgens than estrogens (that's what it does for me)
   b) with topical E2, it's a moot point to generate more E2 locally - oversaturation of receptors is not helpful
   c) it can also have progestogenic effects, which should be avoided in early development.
   
5. It's unclear if RC PPARγ properties would outweigh weak phytoestrogen competing on receptors with topical E2. Localized PPARγ is understudied. Volufiline and adifyline might work or not, but at least they won't compete with estrogen receptors like RC vs E2. And, again, there is no clear evidence that it does.
   
6. IGF levels should be high for the growth. Whether it requires vitamins to be checked is an individual matter. Whether D3 works topically, nobody knows, and with DMSO, it might easily do a D3 poisoning case.
   
7. Nobody knows what's inside BO. It's a soup of dried and ground cow ovaries. One cow is different from another, and no components are controlled. A best it's controlled for food consumption. Solving that powder in ethanol, adding DMSO (which penetrates the skin barrier for large-weight molecules), and punching direct holes in the skin through derma rolling effectively removes body safeguards and introduces unpredictable bio-derived chemistry in the body. Doing it long enough sounds like a recipe for disaster. It can't be possibly recommended.
   
8. Skin penetration accelerants should be avoided as well - insane peaks of E2 are hurting, unsafe, and not helpful. It also opens a door for poisoning where disinfection might not even work.