[Lotus]

Reposting this post for reference and others who've not seen it.

Dhea cream is supposed to restore breast atrophy. It also gives you a bump in your libido. I'd suggest using it in your follicular phase (around day 5 through just prior to the beginning of ovulation), and use an anti-androgen if needed. Start slow and use up 30mg when you've used it a few times. 

Oddly, I saw substantial changes when I did a test run using progesterone cream for about a month. The micronized progesterone I used completely eliminated the fibroids I had in my breasts, it also increased my breast density and firmed my breasts too. Words can't  convey the wonderful feeling you get when you feel the weight and fullness of healthy breasts, I recommend it. 

New information to report on, we already know growth hormone and IGF-1 receptors are in pre and mature adipocytes (aka fat cells). Science indicates progesterone cream triggers GH and IGF-1 in breast tissue. I think perhaps Progesterone needs to be applied in a gel as compared to progesterone cream… which has a poor absorption rate of only 10%, progesterone in gel form has a higher bioavailability. From my experience using my topical protocol it has been a huge benefit. More to follow on all of that. 

Here's my labs from last month. I had normal labs last month (shared a few pages back). I started on Dr. Powers 10% E2 cream about 12 days before I took the these labs, I've never had a more higher Free estradiol number @ percentage @ 2.0% 16.40 pg… total Estradiol was 836 pg/ML and ultra sensitive Estradiol at 1112 pg/ML 

IGF-I was in normal range @ 66 ng/dL (I'm pleased with it, especially considering the health problems I'm battling.)

Thank you Mashtenn and DD's, 

I'd like to share the mammogram results. Lol, the radiologist tech that did the imaging was either anti-trans or was a bit envious?? A robe is supposed to be given when doing a mammogram (per the facilities instructions)... not for me I guess. The technician (middle aged cis-female) says take everything off above the waist (rudely), i say okay (thinking whatever, right?). She has me stand next to a platform where your breasts are situated. She then seems to get perturbed trying to fit my breasts into the imaging plate (for lack of a better term)... my interpretation is she's kneading my boobs like pizza dough, like repeatingly grabbing them from side to side and squishing them. Once the procedure was finished I was told to wait for the results, okay no problem, which I did (about 15 min). The transphobic technician came to the waiting area and said you can go now, your breasts are okay… I said no cancer detected?... she says nope. 

See, I have to tell this story because I always get that transphobic treatment. My first encounter with a doctor (endocrinologist) for hrt treatment (2014) told  me “you know you can those things cut off ”  (meaning my boobs), I said no thank you and requested another doctor, which he refused to offer. I found another hrt doctor thereafter. I heard doctor quack retired shortly after my visit, good riddance too. It's too bad people get treated that way. Now, I see Dr. Powers, (who in my opinion) is hands down the best doctor to see for trans health care. I'm attaching a snapshot of a 3D breast image chart, I fall in-between heterogeneously dense and extremely dense breasts. They're heavy and firm… glandular and not a lot fat. 

MAMMOGRAM DIAG BILAT W/TOMOSYNTHESIS
Collected on January 3, 2024 8:48 AM

Results/Impression
IMPRESSION:NEGATIVE
There is no mammographic evidence of malignancy. A 1 year screening mammogram is recommended. (01/03/2025)
A result summary letter will be sent to the patient.

Narrative

MAMMOGRAM DIAG BILAT W/TOMOSYNTHESIS

MALE DIGITAL DIAGNOSTIC MAMMOGRAM 3D/2D WITH CAD: 1/3/2024

INDICATIONS: Patient has Leukemia.

No prior exams were available for comparison. Current study was also evaluated with a Computer Aided Detection (CAD) system.
No significant masses, calcifications, or other findings are seen in either breast. 

The topical program isn't an overnight success… I got results in the 2nd and 3rd week. But, it may take other users to see results in the 2nd month. Unless you're a mutant and see results within a week.Hopefully I'll be able to find the energy to post more info once I get used to the cancer treatment. Until then  [/font][/color][/size]

Hi Breastnexum family, 3-4 months ago I began reviewing my posts on DHEA and other research I had on it. I wanted to create a topical application program focusing on using HRT hormones and available products to assist in that breast growing program. I can report the combination of DHEA + P4 (micronized progesterone) added 3 inches in new growth in 3 months for myself. I'm listing 3 posts for discussion purposes… please note: it's a long post. Here's a few quotes I'd like to bring attention to. I'll add additional info tomorrow about Bio-labs E1/E2, P4 and 17b applications. 

• application of DHEA that restored atrophy of the breasts and stimulates lobuloalveolar and ductal growth… boob growth". 

• Supplemental DHEA raises estrogen in men and postmenopausal women

• breast size increase was similar to that observed in pregnancy/lactation, so it corresponds to a pretty significant increase of 1-3 digits in cup size. Finally, DHEA did not just increase breast size but it completely reversed the breast atrophy

• DHEA treatment was characterized by a marked stimulation of the ductal and mainly the lobular structures.

• DHEA stimulated lobuloalveolar and ductal growth, as well as the secretory activity of the acinar cells, thus resulting in a lobuloalveolar type of development of the mammary gland.

• Estradiol treatment induced an increased number of ducts (d), accompanied by the presence of alveolar units (a) and small lobules.

• A marked increase in the amount of lobuloalveolar tissue (l) and in the secretory activity of the acinar cells accompanied by accumulation of secretory material (s) in the duct lumen (d) were observed after DHEA administration (F)

• DHEA (5%) in ethanol:olive oil (1:2) was topically applied to the buttock skin of volunteers 12 times over 4 weeks, and was found to significantly increase the expression of procollagen alpha1(I) mRNA and protein in both aged and young skin.

• To investigate the effects of topically applied 17beta-estradiol on the expression of extracellular matrix proteins in aged human skin, 17beta-estradiol (0.01%) and its vehicle (70% propylene glycol, 30% ethanol) were applied to aged (68-82 y, eight females and five males) human buttock skin under occlusion for 2 wk (three times per week). Topical 17beta-estradiol was found to increase the expression of type 1 procollagen mRNA and protein significantly in human aged skin in vivo.

• In conclusion, our results suggest that topical 17beta-estradiol treatment may improve the cutaneous function of aged human skin by improving the connective tissue and increasing epidermal thickness

Dehydroepiandrosterone (DHEA) is the principal human C-19 steroid. DHEA has very low androgenic potency, but serves as the major direct or indirect precursor for most sex steroids. DHEA is secreted by the adrenal gland and production is at least partly controlled by adrenocorticotropic hormone (ACTH). The bulk of DHEA is secreted as a 3-sulfo conjugate dehydroepiandrosterone sulfate (DHEAS). Both hormones are albumin bound, but DHEAS binding is much tighter. As a result, circulating concentrations of DHEAS are much higher (>100-fold) compared to DHEA. In most clinical situations, DHEA and DHEAS results can be used interchangeably. In gonads and several other tissues, most notably skin, steroid sulfatases can convert DHEAS back to DHEA, which can then be metabolized to stronger androgens and to estrogens.

DHEA is C-19 steroid (androgen) but has a very low potency (note to missB). Supplemental DHEA raises estrogen in men and postmenopausal women. But it can also raise androgens (DHT) in some, experienced users know how much to use. DHEA applied topically helps restore breast atrophy in an animal study (see below). I found this in another forum, and it describes an animal study using a topical application of DHEA that restored atrophy of the breasts and stimulates lobuloalveolar and ductal growth… boob growth. The author (haidut, smart fella btw) suggests a 15mg significantly increases all estrogens. Used daily?, I'd be inclined to say a few times per week to start. 

The breast size increase was similar to that observed in pregnancy/lactation, so it corresponds to a pretty significant increase of 1-3 digits in cup size. Finally, DHEA did not just increase breast size but it completely reversed the breast atrophy and other negative tissue changes seen in ovariectomized animals (a rodent model of menopause).

From the study,
DHEA treatment was characterized by a marked stimulation of the ductal and mainly the lobular structures. In addition, epithelial cell hypertrophy and a marked stimulation of secretory activity were seen, these effects being accompanied by the accumulation of clear and eosinophilic vacuoles in the cytoplasm of the acinar cells. - 


DHEA stimulated lobuloalveolar and ductal growth, as well as the secretory activity of the acinar cells, thus resulting in a lobuloalveolar type of development of the mammary gland. - See more at: http://press.endocrine.org/doi/10.1210/endo.139.2.5762?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#sthash.0mwEgt3M.dpuf

Mammary gland histology in (A) intact control, (B) OVX control, and OVX rats treated with © MPA microspheres, (D) estradiol implants, (E) DHT implants, (F) DHEA, 30 mg, cutaneous application, twice daily, on an area of 3 × 3 cm of dorsal skin, (G) DHEA, 30 mg, cutaneous application, twice daily + FLU, 7.5 mg, sc, twice daily and (H) DHEA, 30 mg, cutaneous application, twice daily + EM-800, 250 μg, orally, once daily. An increase in the number of alveolar units (a) was observed in OVX animals treated with MPA © and DHT (E) with the formation of small primitive lobules (l) after DHT administration (E). Estradiol treatment induced an increased number of ducts (d), accompanied by the presence of alveolar units (a) and small lobules (l), without evidence of secretory activity (D). A marked increase in the amount of lobuloalveolar tissue (l) and in the secretory activity of the acinar cells accompanied by accumulation of secretory material (s) in the duct lumen (d) were observed after DHEA administration (F). The stimulatory effect of DHEA on the mammary gland was completely blocked by simultaneous treatment with FLU (G), whereas no significant histological change was seen after the addition of EM-800 to DHEA compared with DHEA alone (H). Compare with intact (A) and OVX (B) controls. Hematoxylin-eosin, magnification ×200(d, ducts; a, alveoli, l, lobules).

Shutting off gonadal function is much easier than you think. The technology is present (in the testes, via Sertoli cells). There is a back door function through 3 beta diol and FSH (follicle stimulating hormone) synthesis. In other words you can turn the testes into an estrogen producing factory.

Here's another example: say you have a situation of testicular failure, giving a supra-physical (massive) dose of testosterone cypionate will result in a cascade conversion to E2.

Hi Lotus,

Ah, so maybe it has happened in humans.

I've posted a couple articles on research I found in this thread:
http://www.breastnexus.com/showthread.php?tid=24439

Grew_some, 

I think it happens IRL but less documented. Picture this hypothetical, if we can modulate a cycle of T to a low point of testicular function, (test result of 50 ng/dl), then add DHEA at a 50 mg dose, add to this a fast of 12-14 hours (which promotes GH), next... the aromatase conversion of DHEA will promote E1/E2 synthesis, 3 beta diol is in this result too. Many other possibilities here.

This scenario is done a few times a week btw, add other products of NBE for synthesis of burning fat and adding adipocytes (thermogenesis).

DHEA usage,  30 mg per day, skin application.

2 studies, similar effect. In any event DHEA looks like it can build a bigger butt, and....,the way it looks, mr. happy can benefit from a topical DHEA solution, oops!  

Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo.
Son ED1, Lee JY, Lee S, Kim MS, Lee BG, Chang IS, Chung JH.
Author information

* 1 Amorepacific Corp/R&D Center, Gyeonggi-do, Korea.
Abstract
To investigate the effects of topically applied 17beta-estradiol on the expression of extracellular matrix proteins in aged human skin, 17beta-estradiol (0.01%) and its vehicle (70% propylene glycol, 30% ethanol) were applied to aged (68-82 y, eight females and five males) human buttock skin under occlusion for 2 wk (three times per week). Topical 17beta-estradiol was found to increase the expression of type 1 procollagen mRNA and protein significantly in human aged skin in vivo. In addition, metalloproteinase (MMP-1 protein levels were reduced by topical 17beta-estradiol. The expressions of TGF-beta1, TGF-beta type II receptor, and Sma and Mad related (Smad)3 were increased by topical 17 beta-estradiol in aged human skin, and TGF-beta1 neutralizing antibody inhibited 17beta-estradiol-induced procollagen synthesis in cultured fibroblasts. We also found that the expressions of tropoelastin and fibrillin-1 mRNA and protein, and elastic fibers in aged skin were also increased by topical 17beta-estradiol. Topical 17beta-estradiol also increased keratinocyte proliferation and the epidermal thickness in aged human skin. We also observed the same effects of topical 17beta-estradiol in young skin. In conclusion, our results suggest that topical 17beta-estradiol treatment may improve the cutaneous function of aged human skin by improving the connective tissue and increasing epidermal thickness.
PMID: 15955089 [PubMed - indexed for MEDLINE]

Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin.

Abstract
Dehydroepiandrosterone (DHEA) and its sulfate conjugate (DHEA-S) are the most abundantly produced human adrenal steroids to be reduced with age. DHEA may be related to the process of skin aging through the regulation and degradation of extracellular matrix protein. In this study, we demonstrate that DHEA can increase procollagen synthesis and inhibit collagen degradation by decreasing matrix metalloproteinases (MMP)-1 synthesis and increasing tissue inhibitor of matrix metalloprotease (TIMP-1) production in cultured dermal fibroblasts. DHEA was found to inhibit ultraviolet (UV)-induced MMP-1 production and the UV-induced decrease of procollagen synthesis, probably due to the inhibition of UV-induced AP-1 activity. DHEA (5%) in ethanol:olive oil (1:2) was topically applied to buttock skin of volunteers 12 times over 4 weeks, and was found to significantly increase the expression of procollagen alpha1(I) mRNA and protein in both aged and young skin. On the other hand, topical DHEA significantly decreased the basal expression of MMP-1 mRNA and protein, but increased the expression of TIMP-1 protein in aged skin. We also found that DHEA induced the expressions of transforming growth factor-beta1 and connective tissue growth factor mRNA in cultured fibroblasts and aged skin, which may play a role in the DHEA-induced changes of procollagen and MMP-1 expression. Our results suggest the possibility of using DHEA as an anti-skin aging agent.

(Source-cantstopeating, ray peat forum)