[Heaven's Night]

Transdermal and injected BIOIDENTICAL estradiol does not elevate blood clotting factors almost at all. Oral estradiol on the other hand does to some extent, but that's likely not an issue either because insane doses aren't usually needed. Topical estrogens elevate local levels mostly so that effect is even more insignificant. Method of admin is a BIG factor on this, so no need to be crazy scared to death about it. Good idea to get bloods done from time to time.