Hi Shirazm (and others),
The following is information on progestins/progestogens. I left some of my concerns too, I do however understand the allure of adding the Opill to one's programs, heck I'd like to try it too… but please be very careful, don't go over the recommended dosage. Also, check the interactions section on supplied instructions. Doing blood tests doesn't really tell you that you're about to develop DVT (deep vein thrombosis). Opill isn’t new, it was originally approved in 1973.
Last suggestion is to be under a doctor's care when doing NBE/HRT. I don't mean to come across as an alarmist, it's just the importance of knowing the pro's and con's of taking that carries risk (as we witnessed one of our own members here diagnosed with DVT from using PM aka- pueraria mirifica)... Apologies in advance.
“ Desogestrel is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.”
The pharmacodynamics and safety of progesterone
P4 and synthetic progestins bind not only to the P4 receptors, but also to many other steroid receptors, including the androgen and mineralocorticoid receptors (MR).
Micronised P4 and synthetic progestins exert their biological effects primarily by binding to progesterone receptors (PRs), the classical genomic pathway, but with different affinities. The variable affinity of progestogens for binding not only to the PR and but also to other members of the steroid receptor family, including glucocorticoid receptor (GR), androgen receptor (AR) and MR, plays a crucial role in differential intracellular progestogen actions (Table 2) [1,27,28].
https://www.sciencedirect.com/science/article/abs/pii/S1521693420300924
Desogestrel reduces SHBG levels, which progestins do. By reducing SHBG you improve free E2 (estradiol) in subsequent target tissues (e.g. brain, ovaries, breast, testes, etc).
Your Guide to Progestin, Progesterone, and Their Roles
https://www.healthline.com/health/womens-health/progestin-vs-progesterone
Risk of venous thromboembolic disease associated with hormonal contraceptives and hormone replacement therapy: a clinical review
Marcelo P V Gomes et al. Arch Intern Med. 2004.
Abstract
Venous thromboembolic events (VTEs) represent a serious complication related to hormonal contraception and hormone replacement therapy (HRT). Evidence on hormonal contraceptive- and HRT-related VTEs is derived almost exclusively from observational studies and points to a 2- to 6-fold increased relative risk of VTEs with either therapy. Oral contraceptive pills that contain third-generation progestins (desogestrel or gestodene) seem to be associated with greater VTE risk than those that contain levonorgestrel. Oral contraceptive pill use and HRT are associated with exponentially higher VTE relative risks when used by women who carry an inherited hypercoagulable state. The indication of a lower or a lack of VTE risk associated with the use of progestin-only contraceptives and with transdermal HRT suggests that these therapies may be safer than combination oral contraceptive pills and oral HRT for women in whom oral estrogen therapy is considered contraindicated. Data that support such safety advantages are limited and should be interpreted with caution.
Krystal, I'm concerned for you (or anyone else) with a history of deep vein thrombosis.
Deep vein thrombosis can be serious because blood clots in the veins can break loose. The clots can then travel through the bloodstream and get stuck in the lungs, blocking blood flow (pulmonary embolism). When DVT and pulmonary embolism occur together, it's called venous thromboembolism (VTE).
https://www.mayoclinic.org/diseases-conditions/deep-vein-thrombosis/symptoms-causes/syc-20352557
The following is information on progestins/progestogens. I left some of my concerns too, I do however understand the allure of adding the Opill to one's programs, heck I'd like to try it too… but please be very careful, don't go over the recommended dosage. Also, check the interactions section on supplied instructions. Doing blood tests doesn't really tell you that you're about to develop DVT (deep vein thrombosis). Opill isn’t new, it was originally approved in 1973.
Last suggestion is to be under a doctor's care when doing NBE/HRT. I don't mean to come across as an alarmist, it's just the importance of knowing the pro's and con's of taking that carries risk (as we witnessed one of our own members here diagnosed with DVT from using PM aka- pueraria mirifica)... Apologies in advance.
“ Desogestrel is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.”
The pharmacodynamics and safety of progesterone
P4 and synthetic progestins bind not only to the P4 receptors, but also to many other steroid receptors, including the androgen and mineralocorticoid receptors (MR).
Micronised P4 and synthetic progestins exert their biological effects primarily by binding to progesterone receptors (PRs), the classical genomic pathway, but with different affinities. The variable affinity of progestogens for binding not only to the PR and but also to other members of the steroid receptor family, including glucocorticoid receptor (GR), androgen receptor (AR) and MR, plays a crucial role in differential intracellular progestogen actions (Table 2) [1,27,28].
https://www.sciencedirect.com/science/article/abs/pii/S1521693420300924
Desogestrel reduces SHBG levels, which progestins do. By reducing SHBG you improve free E2 (estradiol) in subsequent target tissues (e.g. brain, ovaries, breast, testes, etc).
Your Guide to Progestin, Progesterone, and Their Roles
https://www.healthline.com/health/womens-health/progestin-vs-progesterone
Risk of venous thromboembolic disease associated with hormonal contraceptives and hormone replacement therapy: a clinical review
Marcelo P V Gomes et al. Arch Intern Med. 2004.
Abstract
Venous thromboembolic events (VTEs) represent a serious complication related to hormonal contraception and hormone replacement therapy (HRT). Evidence on hormonal contraceptive- and HRT-related VTEs is derived almost exclusively from observational studies and points to a 2- to 6-fold increased relative risk of VTEs with either therapy. Oral contraceptive pills that contain third-generation progestins (desogestrel or gestodene) seem to be associated with greater VTE risk than those that contain levonorgestrel. Oral contraceptive pill use and HRT are associated with exponentially higher VTE relative risks when used by women who carry an inherited hypercoagulable state. The indication of a lower or a lack of VTE risk associated with the use of progestin-only contraceptives and with transdermal HRT suggests that these therapies may be safer than combination oral contraceptive pills and oral HRT for women in whom oral estrogen therapy is considered contraindicated. Data that support such safety advantages are limited and should be interpreted with caution.
Krystal, I'm concerned for you (or anyone else) with a history of deep vein thrombosis.
(15-02-2015, 07:13 AM)krystal3838 Wrote: Simone,
thanks so much...I have been using PM for 6 weeks and have stopped for the time being as I was diagnosed with a blood clot in my left leg last week...I have seen the Hematologist and they will do some tests on my blood next week to see what is the potential cause...I had just ramped up to 2000mgs daily for about a week when I started having symptoms of the clot. Once they determine Pm is not the cause, I plan on starting with the PM again...
I do believe that it is safe, but please be careful...You do have the start of some wonderful growth so do not rush it...smooches...krystal
Deep vein thrombosis can be serious because blood clots in the veins can break loose. The clots can then travel through the bloodstream and get stuck in the lungs, blocking blood flow (pulmonary embolism). When DVT and pulmonary embolism occur together, it's called venous thromboembolism (VTE).
https://www.mayoclinic.org/diseases-conditions/deep-vein-thrombosis/symptoms-causes/syc-20352557