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PS for anyone on high doses of PM saying, "Oh, it's not doing anything," or "I wish it were doing more." While YMMV, pay attention to the rest of your body. I'm no expert, and there are some here who have done their research, but I went topical PM first, then a couple of capsules rectally to bypass the liver, and my thighs are still threatening to cramp or whatever it is they are doing (though to a lesser degree) even today. Barlowe's PM is potent. That's not a complaint, merely a recognition of their potency, my receptiveness and effects. My boobs exploded, but so did a pain in my thighs feeling like a cramp.