14-03-2024, 03:28 AM
(13-03-2024, 02:03 PM)Dibraru Wrote: Now I have another question, do injections give more mood swings than tablets, patches, or gel, or is it all basically the same?
Hi again Dibraru,
A lot of people who take oral E2 experience mood changes, and mostly it's because there's peaks and lows. Meaning oral E2 has a higher peak (known as the term “curve”) with a steep drop off, that's why you'll be taking 2mg tablets 2-3x per day. Taking patches never seems to reach a high curve, so your E2 levels will be low, even with multiple patches. Injectables offer somewhat more steady periods but still have issues. Intramuscular injections have a stronger peak than Subcutaneous injections, however, SUBCUTANEOUS injections have a longer shelf life than IM (Intramuscular). Pellets (inserted 1x per year [on average] have the best steady state of release, per what's been written about it. My doctor does numerous pellet procedures each year, last I heard he has over 4k trans patients, I'll ask him if thata changed (I see him friday). I've left some links you can check yourself. Other things are at play that can contribute to mood swings when on hrt too, like maintaining a healthy BMI, keeping stress low, etc. Good luck
diy hrt
https://diyhrt.wiki/
Intramuscular injection
https://en.m.wikipedia.org/wiki/Intramuscular_injection
Subcutaneous administration
https://en.m.wikipedia.org/wiki/Subcutaneous_administration

