17-12-2022, 04:37 AM
(23-03-2014, 07:01 PM)Lotus Wrote: Men produce 3 mg to 10mg of T per day, and of that 4% gets converted to DHT and .02% gets converted to estrogen, (estradiol)
A number of years I created a thread to highlight the importance of taking Free T and consequently converting it to aromatase by eliminating DHT effects…this is the discussion.
Testosterone 101
https://www.breastnexum.com/showthread.php?tid=20002
That small .02% of E is converted by the enzyme aromatase, this small percentage can be misleading, estradiol is 100 more potent at the receptor sites then T, that means T needs to balance at the same level to have the same affinity.
Let's take 10mg x .02%
It equals 0.002mg of E2 (in serum) in receptor sites the calculations change.
Although naturally-occurring estrogens circulate in the blood largely bound to sex hormone-binding globulin and albumin, only unbound estrogens enter target tissue cells.
(30-03-2014, 05:02 PM)Lotus Wrote: High serum levels of estrogen also trick the brain into thinking that enough testosterone is being produced, further slowing the natural production of testosterone.
This happens when estrogen saturates testosterone receptors in the hypothalamus region of the brain.
The saturated hypothalamus then stops sending out a hormone to the pituitary gland to stimulate secretion of luteinizing hormone, which the gonads require to produce testosterone.
High estrogen can thus shut down the normal testicular production of testosterone…AKA negative feedback.
There's a simpler way to look at this instead of trying to calculate how much aromatase you'll need.
So, in normal human male testes we have the following productions rates:
Testes
Testosterone @ 85%
Estradiol @ 15%
As we start adding phytoestrogens (or hrt meds) to start growing breasts you'll start seeing the above ratios change (evident in blood tests).
Once you reach chemical castration rate of 50 ng/dL that ratio is looking like this:
Estradiol 85%
Testosterone 15%
My advice, take your free T (in the above mentioned ratio) and convert it to aromatase.
Can you still function?...yes, although might need a little help.
Using an anti-androgen that blocks 80-90% of DHT works just fine when used with PM @ 1,000mg. Make sure you follow the entire program in the x-thread (w/no add on's and you'll do just fine).
For additional information, check the x-thread.
I'll have more to follow-up with.

