Hi Venus,
Here's some encouraging nbe news based on science…and not anecdotal as others would have you believe, all the relevant science is posted in the X-thread. But good lord, after reading demon lord's assessment of nbe that would any new person looking for information run for the hills, NBE doesn't have to be difficult or impossible if you have the right information at your disposal. I get the fact of setting realistic expectations, but to say it's all anecdotal (repeatedly) is misplaced.
…changing the path of androgens inside the androgen receptor changes the ratio of androgens to estrogens via aromatase. And this way we improve our success of breast growth.
So what's the magic ratio?, in normal males the ratio is roughly 85% T to 15% E. If you're a numbers person (like me) you'll see how it makes sense using an anti androgen that inhibits DHT by at least 90%, but, as you progress through nbe/hrt this number comes down and reverses that male T ratio to one of which is favorable for breast growth. For instance, you've nukes your junk to oblivion and now the ratio is more like 85% estradiol to 15% testosterone. But...say we want sexual function and still want to feminize, okay, than that ratio will look like this:
45% T
55% E2
Considering that anything below 50ng/dL testosterone reference range for transwomen (per WPATH SOC8) is considered chemical castration, but still, folks below this still range have sex (with some help). Even post-op orchi patients have sex (with some help) and are able to climax, speaking from experience as I am one of those.
If you're over your bmi chances are you have stored estrogen in your fat cells, if you're under your bmi you won't have any estrogen to draw from. So, whatever estrogen or fat you'll need for breast growth will need to be used immediately. If it's nbe it'll have to be PM, and PM will automatically add 15 to 20% triglyceride to your metabolism, so factor that in. Starting slow at 500mg is wise, though I'm extremely concerned about weight and bone mineralization right off the bat. Having less body hair indicate you have too much? meaning an androgen issue?, so any additional information would be helpful, e.g. recent lab tests
Here's some encouraging nbe news based on science…and not anecdotal as others would have you believe, all the relevant science is posted in the X-thread. But good lord, after reading demon lord's assessment of nbe that would any new person looking for information run for the hills, NBE doesn't have to be difficult or impossible if you have the right information at your disposal. I get the fact of setting realistic expectations, but to say it's all anecdotal (repeatedly) is misplaced.
- Picture an androgen signal sent in circulation by the pituitary/hypothalamus axis and makes its way into circulation (blood supply, or other routes…testes). Eventually locating an androgen receptor, when it does it'll cross over cell membranes and into the cytoplasm...now if the androgen molecule doesn't see a 5 alpha reductase inhibitor it'll naturally want to synthesize to DHT before it makes its way into the nucleus, and once inside the mitochondria the deed is done, DHT won.
…changing the path of androgens inside the androgen receptor changes the ratio of androgens to estrogens via aromatase. And this way we improve our success of breast growth.So what's the magic ratio?, in normal males the ratio is roughly 85% T to 15% E. If you're a numbers person (like me) you'll see how it makes sense using an anti androgen that inhibits DHT by at least 90%, but, as you progress through nbe/hrt this number comes down and reverses that male T ratio to one of which is favorable for breast growth. For instance, you've nukes your junk to oblivion and now the ratio is more like 85% estradiol to 15% testosterone. But...say we want sexual function and still want to feminize, okay, than that ratio will look like this:
45% T
55% E2
Considering that anything below 50ng/dL testosterone reference range for transwomen (per WPATH SOC8) is considered chemical castration, but still, folks below this still range have sex (with some help). Even post-op orchi patients have sex (with some help) and are able to climax, speaking from experience as I am one of those.
If you're over your bmi chances are you have stored estrogen in your fat cells, if you're under your bmi you won't have any estrogen to draw from. So, whatever estrogen or fat you'll need for breast growth will need to be used immediately. If it's nbe it'll have to be PM, and PM will automatically add 15 to 20% triglyceride to your metabolism, so factor that in. Starting slow at 500mg is wise, though I'm extremely concerned about weight and bone mineralization right off the bat. Having less body hair indicate you have too much? meaning an androgen issue?, so any additional information would be helpful, e.g. recent lab tests
(19-02-2021, 07:55 AM)Lotus Wrote: Greetings,
I posted this study in 2015 to show the importance of having progesterone in your program. The takeaway here is that without progesterone while taking estradiol and anti-androgen breasts don't mature. Meaning the alveoli, breast ducts and breast buds don't develop to tanner stage 5 potential.
In another study an assay of human male hormone receptors in breast tissue found the following (and this in regards to each being equal to 100%, not the total of the three being @ 100%, follow?).
Breasts
Estrogen receptors @ 94%
Progesterone receptors @ 93%
Androgen receptors @ 57%
So, in human male testes we have the following productions:
Testes
Testosterone @ 85%
Estradiol @ 15%
Anti-androgens inhibit T/DHT between 30-90%. When T is lowered to 50ng/dL and below it is considered chemical castration.
So this is how my thinking goes:
Use progesterone cream to reduce T/DHT in breast tissue.
And in the testes reduce that testosterone from 85% to 5 to 10% using an effective anti-androgen that inhibits @ 80%.
Simple, right?. I believe one could tweak these numbers to how they wish to proceed. Meaning some don't want breast development while others do. We just massage these numbers to create a small imbalance favoring feminization but no breast development, I would do that by just using progesterone cream on the breast...no PM (or estradiol) and an anti-androgen titrated to 45-50% or flip the script geared towards breast growth, and titrate even more for the full feminization.
How's all this for anecdotal
