31-10-2022, 04:52 AM
Hi Siman,
Slathering Progesterone cream is using too much. An ⅛ to ¼ tsp is basically all you need per breast, plus you don't need to use it every day. In a 7 period you chose a 3 or 4 application period, and preferably applied at bedtime because progesterone has mild sedative quality, not like the oral pill has though. The wild yam you're using has diosgenin, which stimulates estradiol, you'll need USP micronized progesterone cream. As it stands the diosgenin is compromising your estrogen receptors in your breasts.
This is true, breast buds aka T.E.B's (terminal end buds) have estrogen and progesterone receptors located in their structure. TEB's are super important during all phases of breast growth but critical in the initial phase of breast growth.
If you're just using a PC, use it for the breasts only, too much can be anti-estrogen. It's up to you whether you want to use PC on your areolas or not, I tried it and didn't like the change in color by using PC on my areolas (too light in color)
Good question, in the male breast there's more progesterone receptors than androgen receptors, but....progesterone is a precursor of androgens so what does that tell you
Sounds like you're on the fence on oral P4 (progesterone). Personally, I don't know if I saw that much of a difference between the pill or the cream...and that includes taking the pill orally or rectally, or taking a dual version of P4 (oral/rectal) simultaneously, but that's me, everyone's different.
MSM helps to restore what progesterone destroys during its protein metabolism. MSM also stimulates GH (growth hormone)
Slathering Progesterone cream is using too much. An ⅛ to ¼ tsp is basically all you need per breast, plus you don't need to use it every day. In a 7 period you chose a 3 or 4 application period, and preferably applied at bedtime because progesterone has mild sedative quality, not like the oral pill has though. The wild yam you're using has diosgenin, which stimulates estradiol, you'll need USP micronized progesterone cream. As it stands the diosgenin is compromising your estrogen receptors in your breasts.
(22-10-2022, 04:40 PM)HelloDiDi Wrote: It was pointed out by Lotus a while back that areolas actually do have progesterone receptors present
This is true, breast buds aka T.E.B's (terminal end buds) have estrogen and progesterone receptors located in their structure. TEB's are super important during all phases of breast growth but critical in the initial phase of breast growth.
(30-10-2022, 04:01 AM)Siman234 Wrote: Is it wise to put progesterone cream on your areola?
If you're just using a PC, use it for the breasts only, too much can be anti-estrogen. It's up to you whether you want to use PC on your areolas or not, I tried it and didn't like the change in color by using PC on my areolas (too light in color)
(30-10-2022, 04:01 AM)Siman234 Wrote: However, applying to the breast seems like it would give more progesterone to the place that matters, the breast tissue. Does that mean an adequate cream dosage to the breast would result in the same level of progesterone in breast tissue as a natal woman?
Good question, in the male breast there's more progesterone receptors than androgen receptors, but....progesterone is a precursor of androgens so what does that tell you
Sounds like you're on the fence on oral P4 (progesterone). Personally, I don't know if I saw that much of a difference between the pill or the cream...and that includes taking the pill orally or rectally, or taking a dual version of P4 (oral/rectal) simultaneously, but that's me, everyone's different.MSM helps to restore what progesterone destroys during its protein metabolism. MSM also stimulates GH (growth hormone)
(28-01-2022, 08:10 AM)Lotus Wrote: There's a difference between USP progesterone and wild yam progesterone. USP progesterone is bioidentical (as in made by humans) as opposed to wild yam made in a lab. WY isn't progestative, apologies. Though in the absence of using estradiol it helps with aveolargenesis (ductal growth).
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Here's some research I put together based on science literature. Progesterone suppresses activation and crosstalk between PR (progesterone receptor) and prolactin/Stat5 signaling to inhibit milk protein gene expression. These changes are reflected in reduced activation of JAK2 and PAK1, resulting in downregulation of pSTAT5.
However, MSM stimulates the activation of the Jak2/STAT5 signaling pathway to help secrete milk protein. MSM also stimulates GH (growth hormone) induced activation of Jak2/STAT5b and prolactin production.
Why is this important?, progesterone downregulates the Jak2/STAT5 pathway that inhibits milk proteins and affect terminal end buds (TEB's which are the branch like structures that fill out breasts) growth and alveologenesis. Taking MSM helps to restore what progesterone destroys during its protein metabolism. We also learned progesterone is catabolic to protein expression in breast tissue. Now we can address this catabolism (breakdown of proteins) by adding amino acids to the mix...possibly tyrosine and proline to strengthen the protein loss. Or possibly consuming more protein in our diet.
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Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
https://pubmed.ncbi.nlm.nih.gov/33282878/
Scribble promotes alveologenesis in the pregnant mammary gland for milk productionScribble promotes alveologenesis in the pregnant mammary gland for milk production
https://pubmed.ncbi.nlm.nih.gov/32213656/
Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells
https://pubmed.ncbi.nlm.nih.gov/19494234/
Jak2 Is an Essential Tyrosine Kinase Involved in Pregnancy-Mediated Development of Mammary Secretory Epithelium
https://academic.oup.com/mend/article/16/3/563/2741654?login=false