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Pandora's Program

#60

(26-09-2022, 12:16 PM)eve_phedrina Wrote:  Can't wait to see how the results are going to be.
Mammary Glandular, Placenta, Ovary Glandular, and Bioperine. I clearly need to start doing some extra research....

Bioperine has some interesting qualities (link to article)

Reversible Testicular Toxicity of Piperine on Male Albino Rats

Determination of serum and testicular hormones were assayed using standard methods.

follicular‑stimulating hormone(FSH)
luteinizing hormone(LH),
testosterone(T)
progesterone(P)
sex hormone‑binding globulin(SHBG)

Treatment
The dose of the piperine was selected according to the investigations
carried out by D’cruz and Mathur, 2005.[29] Adult male rats were divided
into four groups with 12 animals (n = 12) in each group. Group I
(control): Rats were given vehicle p.o., i.e.,0.5% carboxy methyl
cellulose(CMC) in normal saline daily for 60 days. GroupII: Rats were
treated with piperine suspended in 0.5% CMC at a dose of 10mg/kg
b.w. p.o. daily for 60 days (group ED). Group III: Rats were treated
with piperine suspended in 0.5% CMC at a dose of 10mg/kg b.w. p.o.
on every 4thday for 60days(groupE4D). GroupIV: Rats were treated
with piperine suspended in 0.5% CMC at a dose of 10mg/kg b.w. p.o.
on every 7thday for 60days(groupE7D). Half of the animals from each
group were sacriced aer 60 days of treatment. Remaining animals
were kept for the drug‑free withdrawal period of another 60days and
then sacriced(total of 120days). In this study, treatment period was
considered as Phase I and withdrawal period as Phase II


   

   

Quote:.. Oral daily administration of piperine at 10 mg/kg for 60 days caused arrest of spermatogenesis which was accompanied by a significant reduction of sperm motility, count, and viability. Numerous changes in sex hormones levels, spermatogenic cells and testicular enzymes were also observed, indicating suppression of testicular function (Chinta et al. 2017). These results were highly in agreement with previous findings and outcome by Chinta and Periyasamy (2016) that utilized the same conditions (10 mg/kg/day/orally for 60 days to rats), as shown in Tables 3 and 4. Piperine (40) may contribute to the antispermatogenic effects that were produced by piper fruits (4.32-4.96% ...)

Quote: young adult male rats that orally received 10 mg piperine/kg bw/day (suspended in normal saline containing 0.5% carboxymethyl cellulose) for 60 days, Chinta and coworkers observed a statistically significantly (p < 0.05) reduced epididymal sperm count, sperm motility and sperm viability compared to the control group (the latter receiving the vehicle only), accompanied by histopathological changes in the testes and epididymides; statistically significantly increased serum gonadotropins (FSH, LH), with a reduced intratesticular testosterone concentration; and statistically significantly reduced activity of anti-oxidant enzymes or other enzymes in the testes and epididymides

The increase in SHBG is very note worthy. When I first started to take bioperine with all the glandulars, about 3000mg a day,  in 2018 my testicles turned purple. I'm not going to go so hard like that this time around. Slow and steady, gonna mix it up until I find the perfect regiment.
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Messages In This Thread
Pandora's Program - by Pandora56 - 30-03-2018, 07:18 PM
RE: Pandora's Program - by Pandora56 - 31-03-2018, 05:31 AM
RE: Pandora's Program - by Pandora56 - 03-04-2018, 09:09 PM
RE: Pandora's Program - by jannet.duff - 05-04-2018, 10:42 PM
RE: Pandora's Program - by Pandora56 - 05-04-2018, 03:22 PM
RE: Pandora's Program - by Pandora56 - 27-11-2018, 04:31 PM
RE: Pandora's Program - by Pandora56 - 03-12-2018, 04:51 PM
RE: Pandora's Program - by Pandora56 - 11-12-2018, 10:05 PM
RE: Pandora's Program - by Pandora56 - 17-12-2018, 05:00 PM
RE: Pandora's Program - by Pandora56 - 28-12-2018, 05:25 PM
RE: Pandora's Program - by Pandora56 - 29-01-2019, 04:35 PM
RE: Pandora's Program - by Pandora56 - 01-02-2019, 04:58 PM
RE: Pandora's Program - by shaneny - 02-02-2019, 04:20 AM
RE: Pandora's Program - by Pandora56 - 04-02-2019, 05:33 PM
RE: Pandora's Program - by Pandora56 - 06-02-2019, 07:15 PM
RE: Pandora's Program - by julieTG - 06-02-2019, 09:09 PM
RE: Pandora's Program - by michelle street - 07-02-2019, 12:01 AM
RE: Pandora's Program - by Shirazmn - 07-02-2019, 12:14 AM
RE: Pandora's Program - by happyboobs - 07-02-2019, 11:01 PM
RE: Pandora's Program - by Pandora56 - 08-02-2019, 05:49 PM
RE: Pandora's Program - by Pandora56 - 11-02-2019, 08:18 PM
RE: Pandora's Program - by catbeginner - 17-02-2019, 04:03 AM
RE: Pandora's Program - by Brianna29 - 11-02-2019, 10:30 PM
RE: Pandora's Program - by Pandora56 - 12-02-2019, 04:54 PM
RE: Pandora's Program - by PleasantlyFascinated - 12-02-2019, 10:19 PM
RE: Pandora's Program - by Stevenator. - 17-02-2019, 10:13 PM
RE: Pandora's Program - by Pandora56 - 27-03-2019, 01:48 PM
RE: Pandora's Program - by The First Aria - 27-03-2019, 06:04 PM
RE: Pandora's Program - by Pandora56 - 29-03-2019, 04:48 PM
RE: Pandora's Program - by Pandora56 - 23-08-2019, 05:12 PM
RE: Pandora's Program - by PleasantlyFascinated - 26-08-2019, 10:38 PM
RE: Pandora's Program - by MaddieM - 30-08-2019, 06:06 PM
RE: Pandora's Program - by Pandora56 - 18-09-2019, 04:34 PM
RE: Pandora's Program - by Stevenator. - 18-09-2019, 05:32 PM
RE: Pandora's Program - by Stevenator. - 18-09-2019, 05:35 PM
RE: Pandora's Program - by Pandora56 - 18-09-2019, 09:54 PM
RE: Pandora's Program - by Pandora56 - 26-09-2019, 05:01 PM
RE: Pandora's Program - by Pandora56 - 10-10-2019, 09:26 PM
RE: Pandora's Program - by Phanatic - 11-10-2019, 03:27 AM
RE: Pandora's Program - by Pandora56 - 11-10-2019, 01:27 PM
RE: Pandora's Program - by Pandora56 - 12-10-2019, 01:34 PM
RE: Pandora's Program - by Pandora56 - 09-12-2019, 03:58 PM
RE: Pandora's Program - by The First Aria - 11-12-2019, 02:38 AM
RE: Pandora's Program - by Pandora56 - 12-12-2019, 05:32 PM
RE: Pandora's Program - by Pandora56 - 15-01-2020, 03:41 PM
RE: Pandora's Program - by Pandora56 - 02-03-2020, 05:08 PM
RE: Pandora's Program - by Brianna29 - 03-03-2020, 05:11 PM
RE: Pandora's Program - by Pandora56 - 28-04-2020, 06:55 PM
RE: Pandora's Program - by dawn - 28-04-2020, 09:19 PM
RE: Pandora's Program - by britneyvale - 28-04-2020, 09:57 PM
RE: Pandora's Program - by Pandora56 - 18-09-2021, 06:32 PM
Pandora56 - by Pandora56 - 06-09-2022, 03:33 AM
RE: Pandora's Program - by Crystal Amethyst - 08-09-2022, 11:59 PM
RE: Pandora's Program - by Pandora56 - 14-09-2022, 10:36 PM
RE: Pandora's Program - by Crystal Amethyst - 16-09-2022, 12:20 AM
RE: Pandora's Program - by Pandora56 - 19-09-2022, 12:48 AM
RE: Pandora's Program - by Lotus - 20-09-2022, 04:17 AM
RE: Pandora's Program - by Pandora56 - 26-09-2022, 11:36 AM
RE: Pandora's Program - by eve_phedrina - 26-09-2022, 12:16 PM
RE: Pandora's Program - by Pandora56 - 26-09-2022, 02:56 PM
RE: Pandora's Program - by Pandora56 - 28-09-2022, 04:28 PM
RE: Pandora's Program - by Pandora56 - 28-09-2022, 06:12 PM
RE: Pandora's Program - by Pandora56 - 28-09-2022, 06:16 PM
RE: Pandora's Program - by Lotus - 28-09-2022, 06:13 PM
RE: Pandora's Program - by MaleSise - 28-09-2022, 11:21 PM
RE: Pandora's Program - by Pandora56 - 29-09-2022, 03:33 AM
RE: Pandora's Program - by Gabrielle - 30-09-2022, 09:36 AM
RE: Pandora's Program - by Pandora56 - 30-09-2022, 03:49 PM
RE: Pandora's Program - by MaleSise - 29-09-2022, 11:38 AM
RE: Pandora's Program - by Pandora56 - 23-04-2024, 09:12 PM
RE: Pandora's Program - by Pandora56 - 23-04-2024, 09:24 PM
RE: Pandora's Program - by Ninja - 24-04-2024, 02:24 PM
RE: Pandora's Program - by Pandora56 - 26-04-2024, 12:30 AM
RE: Pandora's Program - by Lotus - 23-04-2024, 09:59 PM
RE: Pandora's Program - by Pandora56 - 24-04-2024, 12:15 AM
RE: Pandora's Program - by Lady Charlotte - 26-04-2024, 07:12 PM
RE: Pandora's Program - by Pandora56 - 28-04-2024, 03:45 PM
RE: Pandora's Program - by Pandora56 - 21-05-2024, 07:41 PM
RE: Pandora's Program - by Owllee - 25-05-2024, 05:41 PM
RE: Pandora's Program - by Pandora56 - 27-05-2024, 03:43 AM
RE: Pandora's Program - by CM213 - 21-05-2024, 08:24 PM
RE: Pandora's Program - by CM213 - 21-05-2024, 08:26 PM
RE: Pandora's Program - by Pandora56 - 21-05-2024, 09:01 PM
RE: Pandora's Program - by CM213 - 22-05-2024, 03:21 PM
RE: Pandora's Program - by Connie - 22-05-2024, 07:50 PM
RE: Pandora's Program - by Pandora56 - 23-05-2024, 03:07 AM
RE: Pandora's Program - by Pandora56 - 24-05-2024, 07:02 PM
RE: Pandora's Program - by CM213 - 24-05-2024, 08:53 PM
RE: Pandora's Program - by CM213 - 24-05-2024, 08:58 PM
RE: Pandora's Program - by wee2er - 25-05-2024, 10:14 AM
RE: Pandora's Program - by Pandora56 - 25-05-2024, 03:29 PM
RE: Pandora's Program - by wee2er - 26-05-2024, 12:18 PM
RE: Pandora's Program - by Kay Lady - 26-05-2024, 12:53 AM
RE: Pandora's Program - by Pandora56 - 07-06-2024, 08:46 PM
RE: Pandora's Program - by CM213 - 07-06-2024, 11:00 PM
RE: Pandora's Program - by Melissa24 - 08-06-2024, 06:14 AM
RE: Pandora's Program - by Pandora56 - 30-08-2024, 06:47 PM
Pandora56 - by Pandora56 - 23-04-2025, 04:29 PM
RE: Pandora's Program - by Pandora56 - 27-04-2025, 05:54 AM
RE: Pandora's Program - by Ninja - 27-04-2025, 10:46 AM
RE: Pandora's Program - by Pandora56 - 21-05-2025, 08:47 PM
Pandora56 - by Pandora56 - 06-06-2025, 09:19 PM



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