03-09-2022, 05:35 AM
Hi Mel, belated welcome...if there's such a thing. 
You're estradiol looks really good, mine is the same level as yours and my hrt doc is pleased (not freaked), I'm on low dose .30mg EV subQ injections every 5 days. Your breasts are lovely.
Regarding the prolactin, that's concerning. I hope your doctors are concerned about it too, are they aware of the extra add-ons?. Here's some things to consider, from years of research on MSM I've found the importance of having MSM in ones program:
MSM (Methylsulfonylmethane) enhances the GH-induced activation of Jak2/STAT5b pathway, and oh btw....prolactin takes this very same pathway: This Prolactin Jak2-Stat5 pathway contributes to alveolar development (alveologenesis), additionally, this activation of the prolactin receptor Jak2 (by prolactin) leads to other signaling pathways (e.g. mitogen-activated protein kinase (MAPK) and PI 3-kinase (PI3K) pathways).
Once activated PrlR (prolactin receptor) induces STAT5 phosphorylation (pSTAT5) which is then translocated to the nucleus to regulate the transcription of target genes (Bole-Feysot et al., 1998).
In other words, this pathway will help with alveolar development responsible for breast growth...breast buds (aka: end buds).
Taking into account the multiple items you're taking that's stimulating prolactin I'd trim it down to be safe, not trying to be harsh here...I wouldn't want your doctors calling you wanting an MRI of your brain.
Best wishes Mel,
L.
You're estradiol looks really good, mine is the same level as yours and my hrt doc is pleased (not freaked), I'm on low dose .30mg EV subQ injections every 5 days. Your breasts are lovely.
Regarding the prolactin, that's concerning. I hope your doctors are concerned about it too, are they aware of the extra add-ons?. Here's some things to consider, from years of research on MSM I've found the importance of having MSM in ones program:
MSM (Methylsulfonylmethane) enhances the GH-induced activation of Jak2/STAT5b pathway, and oh btw....prolactin takes this very same pathway: This Prolactin Jak2-Stat5 pathway contributes to alveolar development (alveologenesis), additionally, this activation of the prolactin receptor Jak2 (by prolactin) leads to other signaling pathways (e.g. mitogen-activated protein kinase (MAPK) and PI 3-kinase (PI3K) pathways).
Once activated PrlR (prolactin receptor) induces STAT5 phosphorylation (pSTAT5) which is then translocated to the nucleus to regulate the transcription of target genes (Bole-Feysot et al., 1998).
In other words, this pathway will help with alveolar development responsible for breast growth...breast buds (aka: end buds).
Taking into account the multiple items you're taking that's stimulating prolactin I'd trim it down to be safe, not trying to be harsh here...I wouldn't want your doctors calling you wanting an MRI of your brain.
Best wishes Mel,
L.