12-07-2022, 06:52 AM
(08-07-2022, 06:01 PM)Lotus Wrote: Hi manue,
Getting back to our conversation. Maybe klinefelter's isn't your issue, do you suffer from autoimmune diseases, maybe thyroid?...I know how it impacts testosterone and the pituitary.
Hello Lotus,
I've been checking symptoms for Klinefelter's and Hypertyroidis and I believe we could discard both. I haven't been diagnosed with autoimmune disease and I can tell I'm in overall good health. I have a great metabolism, my anatomy pretty much fits the standard for a Norman. I only hit symptoms sparingly.
(04-07-2022, 04:21 AM)Lotus Wrote: If you're levels are still high there's some plausible explanations, for instance: You're sensitive to estradiol and PM…to determine this it would require screening your DNA using the P450 family of enzymes, or genetic testing [...]
I'm interested in the tests you mentioned.
Looking back though, I can easily associate beyond what Dr. Will Powers demonstrated as what it is to have gender dysphoria. Now trying to analyse my own case and the spike in E2, I'm curious about your mention of potential hypersensitivity to estrogen.
(03-07-2022, 01:05 AM)Lotus Wrote: Plus, when folks start adding more than one estrogen source to a program you run into over expression of estrogen receptors causing a disruption of normal estrogen signaling to the nucleus, meaning stalling your growth. It'll take weeks (maybe months to reset the estrogen receptors).
Could I get more info on this so I can understand this dynamic? I would love to drop phyto if it's truly bad while on HRT. If you could provide me with sources to read I'd love it.<3
I received my latest sample results.
Dosage was, E2 2x4mg sublingual (morning and evening), E2 2mg oral (afternoon) and Bica 12.5mg (morning).
I took the last 2mg E2 sublingual, 500mg PM 12 hours before the sample and 24hrs for Bica. My E2 level was about 470 pmol/L and T at 1.2 nmol/L. The E2 level is good according to my doc but still offered me to up the dosage back to 3x2mg sublingual and follow the same pattern at the next blood sample even though, she thinks it's on the high range.
Thanks for your help.
