04-07-2022, 04:21 AM
Hi Manue and Moobdood,
The thing about lab testing is making sure your blood levels of E2 are at their lowest levels prior to resting. If you're scheduled to take meds the day before lab draws (collection) wait till after the lab work. This is what's called measuring at trough levels. Measuring at trough gives us a clear sense of where hormones are at versus a spike right afterwards taking meds. If you're levels are still high there's some plausible explanations, for instance: You're sensitive to estradiol and PM…to determine this it would require screening your DNA using the P450 family of enzymes, or genetic testing ruling out klinefelter's syndrome. I went through the same thing, I could post more info in your thread if you'd like?
Moobdood you should consider going to subcutaneous injections (not intramuscular), talk to your doctor though, even Dr. Powers recommends going to injections by year 3. I prefer subQ over IM, it's easier to manage. It has a sustained and steady release, which for me avoids the peaks and valleys you'd get using oral E2, plus better bioavailability and feminization. I've also had an orchidectomy like you moobdood.
The thing about lab testing is making sure your blood levels of E2 are at their lowest levels prior to resting. If you're scheduled to take meds the day before lab draws (collection) wait till after the lab work. This is what's called measuring at trough levels. Measuring at trough gives us a clear sense of where hormones are at versus a spike right afterwards taking meds. If you're levels are still high there's some plausible explanations, for instance: You're sensitive to estradiol and PM…to determine this it would require screening your DNA using the P450 family of enzymes, or genetic testing ruling out klinefelter's syndrome. I went through the same thing, I could post more info in your thread if you'd like?
Moobdood you should consider going to subcutaneous injections (not intramuscular), talk to your doctor though, even Dr. Powers recommends going to injections by year 3. I prefer subQ over IM, it's easier to manage. It has a sustained and steady release, which for me avoids the peaks and valleys you'd get using oral E2, plus better bioavailability and feminization. I've also had an orchidectomy like you moobdood.