[Manue]

Manue,

this is really a bad idea, this study found that Donyu Rats using PM (the study you quoted from) reported PM causes mammary carcinogenesis...aka cancer. If moobdood simply spoke with her doctor they would advise against using a phytoestrogens with bioidentical estrogen...ever. And I continually address using this approach as it competes with estrogen receptors. Bioidentical estrogens bind more correctly to estrogen receptors than do phytoestrogens, I know some science reports otherwise, but as someone who's been on nbe and hrt the effects of hrt are more dramatic on hrt than nbe...it just takes more time, folks have to be patient. Plus, when folks start adding more than one estrogen source to a program you run into over expression of estrogen receptors causing a disruption of normal estrogen signaling to the nucleus, meaning stalling your growth. It'll take weeks (maybe months to reset the estrogen receptors). 

Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127102/

Hello Lotus,

Didn't they use insane amounts of PM to arrive to that statement? To me, the title is very misleading concerning human use of PM. The citation about outcompeting comes from research that has paywall. Do you know any other source on the topic?

I haven't recommended Moobdood to take PM, I was simply addressing their concern on the matter based on my own experience. What I recommended was to look into taking E2 sublingually to get higher levels as it does seem to be their aim. Their judgement.

I don't know if you read my diverse threads on the matter, but in my last sample, I hit 2173 pmol/L E2 from only 3x2mg E2 tablets. It is way too high when the target is 1300 pmol/L. I even had to take P5P to tune down nausea. I was taking 500mg PM and 600mg WP the night before and also about 2000mg Alfalfa in the morning of the sampling. If phytos are an issue, do you have another explanation for this?

Is there somewhere I could read about diverse sources of E would run into over expression of the E receptors causing a disruption of normal estrogen signaling to the nucleus?

Regards