[Manue]

Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats

Trophic effects of estrogenic compounds on the mammary gland and uterus were previously suggested to be due to activation of signaling through estrogen receptors (ERs) ERα and ERβ [17]. It was reported that PM phytoestrogens at high doses could effectively outcompete 17 β-estradiol binding to ERα in MCF-7 cells [3].

the second group of coumestans comprises coumestrol, mirificoumestan, mirificoumestan glycol, and mirificoumestan hydrate; and the third features chromenes, such as miroestrol, deoxymiroestrol, and isomiroestrol [2]. All these substances are phytoestrogens with structures similar to that of 17 β-estradiol. Miroestrol, the phytoestrogen with the highest estrogenic activity among all those isolated from PM, is considered similar to estriol, which is considered the safest estrogen for humans [4,5,6,7]. Furthermore, PM has been reported to contain phytoestrogens like β-sitosterol, stigmasterol, campesterol, as well as the cytotoxic non-phytoestrogen spinasterol [3,8].

Good evening!

I'm probably alone in the world reading scientific articles on a Friday night but here we go.

Those points have probably been discussed in the Lotus' Project X thread. They provide the answers as to why it isn't picked up by a simple Estradiol test that is also suppressed by PM.

Those are my questions right now :

1. What good is Aromatase doing if Estradiol is being suppressed by the larger doses of PM?
   
2. Is it possible that my Testosterone was low because I took my 1st cycle of supplements as well as Finasteride 1 hour before my blood test?
   
3. Could a low dose PM bring mild benefits (Pro-Aromatase, AA) when taken alongside a dominant Estradiol?
   
4. Could Pro-Aromatase herbs like White Peony become irrelevant when taking larger doses of PM?