[Lotus]

Hi there ukxdress, 

If PM causes you trouble I'd steer clear of using it in any form. Why not try progesterone cream?. Human skin has DHT, progesterone cream inhibits DHT and resets estrogen receptors. As stated elsewhere, taking PM with FG is redundant, they are competing for the same receptor. Plus, adding PC makes sense because FG lowers progesterone. 

Hey Lotus
I thought since FG raises estradiol, wouldn't that be taken when E rises? But you're also saying it raises P-- so I am a bit confused lol (sorry) this whole time I thought FG worked on E and should be taken during follicular?

Do you think FG extract should be cycled the same way because it would have the same effect? I have been considering Fenu extract, flaxseed and hops oils (all topical)

Hey there missB,

The science from the study indicates estradiol (in the second month) was raised by 50%(my calculations) @ 600 mg a day for two menstrual cycles. Btw, FG needs to be at least 50% steroidal saponins. (NOTE-that's not a misprint, only 600 mg was used).

 steroidal saponins reported to exhibit estrogenic effects including binding to E2 receptors and inducing the expression of E2 responsive genes (Sreejaet al., 2010). 

It raises prolactin yes, though not as significant as estradiol. From the study, FG lowers cholesterol, SHBG, progesterone and FSH (follicle stimulating hormone). It also raises LH (luteinizing hormone @ 41%)...thus the need for additional 5 AR inhibitors.

 I'll have to adjust the supplement info about FG lowering progesterone. Alternatively, I'd take FG with a conversion supplement (pro-aromatase) considering what it does to FSH, which synthesizes aromatase. I'm excited about a new aromatase approach using EPO and peanut oil, though I'm looking for an alternative for those with peanut allergies. What the 2 combination does is its binding ability in EGF (epidermal growth factor). I'll post more info on the X thread. 

Topical FG is OK (though much DHT is in the skin). Use a good skin penetrator that inhibits 5 Alpha Reductase (inhibits DHT) too...EPO (evening primrose oil) could work. The study size was 80 premenopausal women.  

https://www.breastnexus.com/showthread.php?tid=26172&page=2