[JustAbbey]

Hi Lotus, thanks for the kind note - I certainly don’t have the knowledge you do!

I will say your recent thoughts on creams also had me researching a bit. I’m curious about the link between progesterone and lobule/duct development. I’ve seen a number of conflicting research papers: Sonnenblick et al. 2018 seems to indicate HRT with progesterone in men will lead to identical breast structure as cisgender women, while a bunch of others seem to indicate only the fibrous dense tissue is formed in men regardless of HRT regimen. Certainly typical gynocomastia seems to be only dense tissue, so I was curious if the progesterone supplementation is the differentiator for lobule development?

If so, it seems like progesterone would be required not just to further nodule/dense tissue growth, but also to foster lobe/duct development for a ‘full’ breast.

Also curious, have you seen any other research on P/E affecting adipose tissue composition when applied transdermally? I’ve seen recommendations against applying where there is a lot of subcuteneous fat (likely affecting absorption), but am curious if it would have positive growth effects on adipose tissue that is E sensitive? And inversely, if it would impact fat distribution in android regions that is typically more T sensitive?

Thanks much!