[Lotus]

Boom. Thanks for chiming in. But I'm not following - due to the formatting, I can't tell which bits you've pasted from your sources and which ones are your comments on the subject, but does this one...

Pueraria mirifica needs liver activation for the chromene compound miroestrol/deoxymiroestrol to become active...it has to activate certain enzymes to become biologically active. 

...mean that liver metabolism is necessary then? If so, does that mean that my only option is to take PM orally, take a blood thinning supplement (like Rutin) and take my chances? If so, that's not great news.

Ah, I see. I compose offline, without quotations, it's just less hassle. The liver activation is from me, but comes from science studies. 

No, not necessarily the only option. As I recommended and try the suppository method. The fast metabolism via water/PM 
is too fast..maybe puts oneself at higher risk for side effects. We want a slow approach that will have meaningful results, and hopefully no side effects. The first pass metabolism eliminates 90% of supplements. Your plan will have a liver activation...that's a plus because they'll be more PM there to use. Do use a fatty acid for making a DIY suppositories, like coconut oil/ or olive oil. YouTube has some good videos on the how too. Just search DIY rectal suppository. Just remember, there is such a thing as micronized rectal estradiol suppository...so you're on the right track.

Apologies on the format. Hope this helps