[thegirl1951]

There are some things to think about here:

As Drew points out, you must make sure it ends up in the lower, or "inferior" part of the cavity versus the upper or "superior" part. The lowest 5 cm is where you want it. There are three "levels" of the rectum, each being about 5 cm long. This is not because administering it to the upper portions is "useless"; it has to do with the critical need to bypass some liver metabolism, I think (can't remember). I just did a bunch of research on this and my head is spinning. Here's a note from Wikipedia:

"A drug that is administered rectally will in general (depending on the drug) have a faster onset, higher bioavailability, shorter peak, and shorter duration than oral administration.[1][2] Another advantage of administering a drug rectally, is that it tends to produce less nausea compared to the oral route and prevents any amount of the drug from being lost due to emesis (vomiting). In addition, the rectal route bypasses around two thirds of the first-pass metabolism as the rectum's venous drainage is two thirds systemic (middle and inferior rectal vein) and one third hepatic portal system (superior rectal vein). This means the drug will reach the circulatory system with significantly less alteration and in greater concentrations."

It's a mistake to inject it "as far up there as possible" - might as well take it orally at that point.

There's a potential downside to this concept. As can read above, rectal administration means faster onset and shorter peak. Not sure how that factors into the way estrogen should be absorbed. Does this mean it would be better to "inject" a tiny amount several times a day? That would be unreasonable.

I'm hoping someone with more knowledge on the subject (or willing to do more research) chimes in. With all that being said, taking the supplement Rutin is reported to be effective in preventing clotting issues - and it's way way cheaper than the pharma alternatives.

Just a thought WRT clotting: wouldn't low dose aspirin (81mg) be effective as an anticoagulant?  I could not find anything about Rutin as an anticoagulant in a quick web search.