[Lotus]

This post is for anyone wishing to lactate.

 Prolactin is basically stimulated by the paraventricular nucleus via the hypothalamus, (I won't describe prolactin inhibiting hormone because dopamine is the same thing). Basically Thyrotropin Releasing Hormone (TRH) is essentially passed on by the anterior pituitary to be released the lactotrope cell inside the anterior pituitary and on out via blood supply.

Things needed to produce breast milk:

1) Estrogen
2) Inhibiting dopamine 
3) TRH- Thyrotropin releasing hormone 
4) Breast feeding (some BN members use pumps, use the BN search to find threads).

What's cool is that when dopamine is inhibited the secretion of Adenylyl Cyclase is stimulated (much in the same way alcar works) to stimulate ATP production. But...that pesky PDE stops ATP synthesis in the mitochondria, unless we use a PDE inhibitor.

So D1 agonists (promoters) inhibit dopamine (D2 inhibitors are too risky to use). Which in this case D1 agonists stimulates protein kinase C (PKC), in other words PKC stimulates aromatase too. My plan is skipping inhibiting dopamine and stimulating it with PKC, sorta leapfrogging dopamine, it's already been proven. There's a PKC promoter that fits the bill. Since D1 agonists stimulate Adenyl Cyclase which then produces ATP and aromatase we don't need dopamine for stimulating prolactin because dopamine is messy.

Inhibiting dopamine raises prolactin. Estrogen raises prolactin too, but high levels of estrogens inhibit prolactin. In the process of prolactin stimulation alveolar glands (lobules) get bigger. Ironically MSM stimulates what's known as the Jak2/STAT pathway, and this pathway stimulates alveolar glands (housed inside the lobules) via the portal blood system...this is good as it helps with protein synthesis. We need further protein synthesis of alveolar glands to generate such things as Iga-1, milk proteins, vitamins, cholesterol, lactoferrin (etc) so that breast milk can be produced. We also need ATP in this protein synthesis, but that goes back to describing the citric acid cycle (aka krebs cycle), lol, that's covered in an earlier post. 

Once protein synthesis is released to lumen then its on the way out of the lactiferous ducts to express milk.

So, if you take an antidepressant, thyroid medication, or estrogen you're almost there. The PKC (protein kinase C) is Forskolin. but, not all Forskolin is created equal. 

I can see MSM playing a part here. I don't have the particular dosages needed on estradiol, MSM or antidepressants or forskolin just yet. But I do see forskolin as an herbal replacement for estradiol as it being a pro-aromatase herb. 

@ troublewithnibbles- from experience not all melatonin is created equal too, meaning some seem more effective than others. 

@ AWOO, you're welcome, and good to see you posting again.

@ Pleasantlyfascinated, lol, I'm on it.