[Lotus]

Hi Jannet, 

Both oral and skin applications (to breasts) are viable options for NBE. I've updated the following post to include information about pumping and the molecular weight of aloe vera.

Btw, for those whose domes steam up during pumping I've determined it's a build up humidity, thus water (ambient air-inside the dome) being pulled into the breast. I also believe it's in part relevant to thermogenesis (or heat transfer) aiding synthesis of mitochondria...(I could be wrong though). I also believe after pumping breasts need to be compressed for tissue repair (think collagen matrixing) and so I prefer a sports bra. And when I research tissue repair I find that after breast augmentation surgery the wrap breasts up for tissue adhesion, thus the reason for the sports bra. IMHO this concept works better with B-cup and above. The whole premise of pumping is built around stretching fat cells so as blood enters the fat cell thus carrying nutrients into the fat cell. Well that's all fine dandy, but stretched breasts need to build the necessary collagen matrix. 

And here's where aloe vera comes in. Of the 75 compounds collagen is one of them, and I explain how it can be used for NBE.

Collagen is the major protein in the extracellular matrix (ECM) of various connective tissues. It was observed that aloe vera increases the collagen content of the granulation tissue as well as its degree of crosslinking [13]. Aloe vera stimulates fibroblasts for regeneration in a synovial model [17], and enhances tensile strength and collagen turnover in damaged tissues [61]. In another trial using topical application, aloe vera gel stimulated fibroblast activity and collagen proliferation [16].

Aloe Vera for Tissue Engineering Applications
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371879/

The 500 Dalton rule for the skin penetration of chemical compounds and drugs
Authors
* Jan D. Bos, Marcus M. H. M. Meinardi
* First published: June 2000Full publication history
* DOI: 10.1034/j.1600-0625.2000.009003165.xView/save citation
* Cited by: 370 articles

Jan D. Bos, Department of Dermatology A0-235, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands
Tel.: +31 20 566 2587. Fax: +31 20 696 0076
e-mail: j.d.bos@amc.uva.nl
Abstract
Abstract: Human skin has unique properties of which functioning as a physicochemical barrier is one of the most apparent. The human integument is able to resist the penetration of many molecules. However, especially smaller molecules can surpass transcutaneously. They are able to go by the corneal layer, which is thought to form the main deterrent. We argue that the molecular weight (MW) of a compound must be under 500 Dalton to allow skin absorption. Larger molecules cannot pass the corneal layer. Arguments for this “500 Dalton rule” are; 1) virtually all common contact allergens are under 500 Dalton, larger molecules are not known as contact sensitizers. They cannot penetrate and thus cannot act as allergens in man; 2) the most commonly used pharmacological agents applied in topical dermatotherapy are all under 500 Dalton; 3) all known topical drugs used in transdermal drug-delivery systems are under 500 Dalton. In addition, clinical experience with topical agents such as cyclosporine, tacrolimus and ascomycins gives further arguments for the reality of the 500 Dalton rule. For pharmaceutical development purposes, it seems logical to restrict the development of new innovative compounds to a MW of under 500 Dalton, when topical dermatological therapy or percutaneous systemic therapy or vaccination is the objective.
http://onlinelibrary.wiley.com/doi/10.1034/j.1600-0625.2000.009003165.x/abstract

Molecular Weights: (g/mol)

Aloe Vera- 270.24

Palmitic- 270.46

Stearic - 298.52

Oleic - 282.46 

Linoleic - 298.48

Almond oil - 106.12

Estradiol - 272.4

Soybean oil -292.2

http://biodiesel.org/docs/ffs-performace_usage/chemical-weight-formula.pdf?sfvrsn=4