[Lotus]

I haven’t yet taken the time yet to explore and digest the provided links, but am confused by the connection you are making.

My dietary practice has been ketogenic for at least three years. I use MSM by the kilo (8000 mg./day).  I use 1000 mg. Acetyl L-Carnitine daily.  I use reishi, saw palmetto, progesterone daily, stinging nettle, and likely several other things that curtail DHT conversion.  I even have a mild addiction to a small amount of topical estriol daily.

I have noticed effects, but not any boob growth.  Should I have? Not that I am trying for breasts.  Rather, this now has me mildly concerned.

I like the fact that you're using MSM, reishi, L-carnitine, progesterone (though I would suggest using only 3 days per week), stinging nettle and maybe even the estriol cream. Personally I think saw using palmetto and the other DHT stuff you mention is redundant. You see stinging nettle (from my research is a pro-aromatase, and I'll explain why). Stinging nettle is a PDE inhibitor, PDE stands for phosphodiesterase, which PDE is present in every cell, however PDE wants to shut the the second messenger signal of cAMP
(cyclic adenosine monophosphate), which is pro-aromatase, so using a PDE inhibitor like stinging nettle it potentiates the action of aromatase.

Quote:
membrane estrogen receptors initiate signal cascades directly via conventional second messengers, which include adenylate cyclase, cyclic adenosine monophosphate (cAMP), phospholipase C, protein kinase C, and mitogen‐activated protein kinase (MAPK), producing rapid responses to phytoestrogens (Sirotkin, 2016; Yanagihara et al., 2014).

cyclic AMP (cAMP) is a common second messenger involved in signal transduction cascades.

cAMP is synthesized from ATP by the enzyme adenylyl cyclase, which resides in the cell membrane.

activation of adenylyl cyclase can result in the manufacture of hundreds or even thousands of cAMP molecules

Activation of receptors can trigger the synthesis of small molecules called second messengers, which initiate and coordinate intracellular signaling pathways. For example, cyclic AMP (cAMP) is a common second messenger involved in signal transduction cascades. (In fact, it was the first second messenger ever discovered.) cAMP is synthesized from ATP by the enzyme adenylyl cyclase, which resides in the cell membrane. The activation of adenylyl cyclase can result in the manufacture of hundreds or even thousands of cAMP molecules. These cAMP molecules activate the enzyme protein kinase A (PKA), which then phosphorylates multiple protein substrates by attaching phosphate groups to them. Each step in the cascade further amplifies the initial signal, and the phosphorylation reactions mediate both short- and long-term responses in the cell (Figure 2). How does cAMP stop signaling? It is degraded by the enzyme phosphodiesterase.
https://www.nature.com/scitable/topicpag...-14047077/

Good to see you've adopted keto, I've been on it for a few years. Do you incorporate IM (intermittent fasting) and exercise?. If you're in ketosis you shouldn't need exogenous-ketones supplements. I would encourage you to test your testosterone and estradiol, just to see what the current results look like from your regime, knowing those results can identify specific goals you want to achieve.

I would also suggest using a organic bone broth, glucosamine (which I can explain later), vitamin D with organic olive oil (not soybeans oil), Calcium citrate, (not Calcium carbonate which neutralizes stomach acid), monitor mineral intake. Pharma meds can inhibit/and or help NBE, just depends what's prescribed to you.