[Lotus]

So, White Peony & Lemon Water are better AA options now?

Hi Stevenator, remember these posts?...WP (it should be standardized above 10%) inhibits DHT and prostate cancer cells and is pro-aromatase, lemon water stems from research posted below, green tea plus lemons is a good strategy too. Reishi is also a good choice imo.

Gut health is supremely the first step towards solid nbe/hrt plan...stary with a Neutral PH balance and then add a good probiotic, though if you take Metformin you shouldn't need the probiotic.

So what is the best way to take advantage of the CYP's ?

Here's a couple examples of foods explaining the P450 Cytochromes enzymes, the goal is to map out as much as we can. Ultimately in the future we'd know ahead of time what medicines works best/worst by a simple lab test. Maybe the costs will be lower with more competitors joining the market?.

Here's another example of how interactions can happen, multiplying its effects. Say you drink green tea (a CYP17 inhibitor of testosterone). Now because you add piperine (in certain supplements, or added by supplementing) it increases the EGCG (polyphenols) in green tea by 1.3 fold.


J Nutr. 2004 Aug;134(8):1948-52.
Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice.
Lambert JD1, Hong J, Kim DH, Mishin VM, Yang CS.
Author information
Abstract
(-)-Epigallocatechin-3-gallate (EGCG), from green tea (Camellia sinensis), has demonstrated chemopreventive activity in animal models of carcinogenesis. Previously, we reported the bioavailability of EGCG in rats (1.6%) and mice (26.5%). Here, we report that cotreatment with a second dietary component, piperine (from black pepper), enhanced the bioavailability of EGCG in mice. Intragastric coadministration of 163.8 micromol/kg EGCG and 70.2 micromol/kg piperine to male CF-1 mice increased the plasma C(max) and area under the curve (AUC) by 1.3-fold compared to mice treated with EGCG only. Piperine appeared to increase EGCG bioavailability by inhibiting glucuronidation and gastrointestinal transit. Piperine (100 micromol/L) inhibited EGCG glucuronidation in mouse small intestine (by 40%) but not in hepatic microsomes. Piperine (20 micromol/L) also inhibited production of EGCG-3"-glucuronide in human HT-29 colon adenocarcinoma cells. Small intestinal EGCG levels in CF-1 mice following treatment with EGCG alone had a C(max) = 37.50 +/- 22.50 nmol/g at 60 min that then decreased to 5.14 +/- 1.65 nmol/g at 90 min; however, cotreatment with piperine resulted in a C(max) = 31.60 +/- 15.08 nmol/g at 90 min, and levels were maintained above 20 nmol/g until 180 min. This resulted in a significant increase in the small intestine EGCG AUC (4621.80 +/- 1958.72 vs. 1686.50 +/- 757.07 (nmol/g.min)). EGCG appearance in the colon and the feces of piperine-cotreated mice was slower than in mice treated with EGCG alone. The present study demonstrates the modulation of the EGCG bioavailablity by a second dietary component and illustrates a mechanism for interactions between dietary chemicals.

http://www.ncbi.nlm.nih.gov/pubmed?filters=&orig_db=PubMed&cmd=Search&term=134%2A%5Bvolume%5D%20AND%201948%5Bpage%5D%20AND%202004%5Bpdat%5D%20AND%20Lambert%20JD%5Bauth%5D

Hi BN,

Here's another idea to try..........." citrus for breast growth ". These enzymes C(17,20)-lyase  cyp 17, cyp 19, cyp 3A4 have direct pathways to breast/androgen synthesis. Cyp 3A4 controls more than 50% of how drugs are metabolized (I'd say that's a major regulator to piggy back off of), the only issue there is mapping out all these key regulators, (like mapping out the genome).


Example: star fruit inhibits CY3A, more potent than grapefruit,(as stated above inhibiting CY3A4 will help with breast growth).


Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity.
Hidaka M1, Fujita K, Ogikubo T, Yamasaki K, Iwakir

The C(17,20)-lyase...controls biosynthesis of androgens by both the testes and adrenals. A complete inhibition of this enzyme would provide an alternative means of androgen suppression for the treatment of prostatic cancers.

Effect of paeoniflorin, glycyrrhizin and glycyrrhetic acid on ovarian androgen production. - 
https://www.ncbi.nlm.nih.gov/m/pubmed/1897494/z