19-10-2017, 02:15 PM
All that vitamin B6 in those formulations can be problematic, and potentially compounded if taking multiples of these a day.
Adverse effects have been documented from vitamin B6 supplements, but never from food sources. Although it is a water-soluble vitamin and is excreted in the urine, doses of pyridoxine in excess of the UL over long periods of time result in painful and ultimately irreversible neurological problems. The primary symptoms are pain and numbness of the extremities. In severe cases...difficulty in walking. Sensory neuropathy typically develops at doses of pyridoxine in excess of 1,000 mg per day, but adverse effects can occur with much less, so doses over 200 mg are not considered safe.
https://en.wikipedia.org/wiki/Vitamin_B6#side_effects
Adverse effects have been documented from vitamin B6 supplements, but never from food sources. Although it is a water-soluble vitamin and is excreted in the urine, doses of pyridoxine in excess of the UL over long periods of time result in painful and ultimately irreversible neurological problems. The primary symptoms are pain and numbness of the extremities. In severe cases...difficulty in walking. Sensory neuropathy typically develops at doses of pyridoxine in excess of 1,000 mg per day, but adverse effects can occur with much less, so doses over 200 mg are not considered safe.
https://en.wikipedia.org/wiki/Vitamin_B6#side_effects