04-03-2017, 03:23 AM
Casodex is flutamide (pharma anti-androgen), DIM is " remarkably similar in conformational geometry and surface charge distribution " to pharma casodex (flutamide). So....yes, the op's original question taking DIM with PM could be effective,........and useful for HRT mtf's.
DIM is Diindolylmethane. It is an anticarcinogen and also improves estrogen metabolism. Plant-derived 3,3′-Diindolylmethane Is a strong Androgen Antagonist in Human Prostate Cancer Cells* DIM is remarkably similar in conformational geometry and surface charge distribution to an established synthetic AR antagonist, although the atomic compositions of the two substances are quite different. Taken together with our published reports of the estrogen agonist activities of DIM, the present results establish DIM as a unique bifunctional hormone disrupter. To our knowledge, DIM is the first example of a pure androgen receptor antagonist from plants.
http://www.jbc.org/content/278/23/21136.full
It is interesting to note that the antiproliferative and anti-androgenic activity of DIM in LNCaP cells were observed at physiologically relevant concentrations. A man of average weight who consumes 200g of broccoli daily will obtain 12 mg of DIM. With maximum absorption of DIM, the blood concentration of DIM would be as high as 10 Mg. Therefore, in vivo concentrations of DIM from dietary Brassica vegetables repre- sent the effective levels of DIM in vitro.
http://www.jbc.org/content/278/23/21136.full.pdf
• How is hormonal sex reassignment achieved for male-to-female transsexuals?
Hormonal therapy is prescribed for male-to-female transsexuals to induce breast formation and a more female distribution of fat and to reduce male-pattern hair growth. To achieve these goals, the biologic action of androgens must be almost completely neutralized. Administration of estrogens suppresses gonadotropin output and therefore androgen production, but combining this treatment with a progestational agent, a gonadotropin-releasing-hormone (GnRH) analogue, or other medications that suppress androgen action (e.g., cyproterone acetate, flutamide, nilutamide, or bicalutamide) appears to be more effective.
http://blogs.nejm.org/now/index.php/3139/2011/04/01/
DIM is Diindolylmethane. It is an anticarcinogen and also improves estrogen metabolism. Plant-derived 3,3′-Diindolylmethane Is a strong Androgen Antagonist in Human Prostate Cancer Cells* DIM is remarkably similar in conformational geometry and surface charge distribution to an established synthetic AR antagonist, although the atomic compositions of the two substances are quite different. Taken together with our published reports of the estrogen agonist activities of DIM, the present results establish DIM as a unique bifunctional hormone disrupter. To our knowledge, DIM is the first example of a pure androgen receptor antagonist from plants.
http://www.jbc.org/content/278/23/21136.full
It is interesting to note that the antiproliferative and anti-androgenic activity of DIM in LNCaP cells were observed at physiologically relevant concentrations. A man of average weight who consumes 200g of broccoli daily will obtain 12 mg of DIM. With maximum absorption of DIM, the blood concentration of DIM would be as high as 10 Mg. Therefore, in vivo concentrations of DIM from dietary Brassica vegetables repre- sent the effective levels of DIM in vitro.
http://www.jbc.org/content/278/23/21136.full.pdf
• How is hormonal sex reassignment achieved for male-to-female transsexuals?
Hormonal therapy is prescribed for male-to-female transsexuals to induce breast formation and a more female distribution of fat and to reduce male-pattern hair growth. To achieve these goals, the biologic action of androgens must be almost completely neutralized. Administration of estrogens suppresses gonadotropin output and therefore androgen production, but combining this treatment with a progestational agent, a gonadotropin-releasing-hormone (GnRH) analogue, or other medications that suppress androgen action (e.g., cyproterone acetate, flutamide, nilutamide, or bicalutamide) appears to be more effective.
http://blogs.nejm.org/now/index.php/3139/2011/04/01/