[Lotus]

When to supplement (timing)
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Typically, hormones are released every 90 minutes, the binding of receptors takes 30-60 minutes upon activation. The process of supplementing should match that cycle (e.g. supplement every 4 hrs to correspond with the cycle rather than taking all at once, or in large dose).

For further information about timing and receptors please see the following:

Receptor Regulation (how the timing of hormones work)
http://www.breastnexus.com/showthread.php?tid=20747&page=5