[Lotus]

Nice find Jamie, my opinion is that it's a potentiator (makes stronger) of hormones mentioned. It looks to be helpful for females and MtF's, an increase of T in male mice was noted, which can be converted to estrogen as we know. What's the cost?

In the present study, concentrations of estradiol-17β and progesterone for P. paniculata-fed mice were significantly higher than those for control mice. Testosterone can be synthesized from progesterone and used to synthesize estradiol-17β. Therefore, the fact that the plasma concentrations of estradiol-17β and progesterone increased in female mice suggests an increase in the plasma concentration of testosterone in male mice. In humans, saponins can relieve impotency [4], and this could be attributable to increased plasma testosterone levels. This is an indirect effect of saponins on the testis and an indirect effect of adaptogens on testosterone [21]. In the present study, plasma concentrations of testosterone for P. paniculata-fed mice were significantly higher than those for control mice. Oral intake of P. paniculata therefore significantly increases levels of male and female sex hormones (estradiol-17β, progesterone and testosterone).


PDF (full study)
Pfaffia paniculata-induced changes in plasma estradiol-17beta, progesterone and testosterone levels in mice.
https://www.jstage.jst.go.jp/article/jrd...2_175/_pdf