[Lotus]

Thank you pino for the feedback, advise and compliments (I appreciate that).


Random trials are being conducted on a daily basis (here at breast nexus), cheers to the folks who report their progress (good, bad or indifferent).  I'm under no illusions that anybody  wants or needs to hear advice from me, I have my own questions of NBE/HrT—what if? (fill in the blank_________), my opinions are that, my own.

Pino, you enjoy documenting (photographing) your own personal experience, I prefer finding juicy abstracts benefiting NBE and health.

Good research should represent a language anybody can understand, sadly, technical jargon largely inhibits progressive acceptance and interpretation. On the other-hand, there's the ubiquitous ambiguity of Pharmacokinetics. My dealings with BO are less ambiguous as ever, i was foolhardy to follow advice about how much to take and not realizing the risks involved. Even less unique to my own personal experience with NBE and BO is how the archives are filled with negative personal experiences, we'd be foolish NOT to share results if we knew it could help inform others.

Wouldn't we all want to take less supplements?, I see targeting therapeutic ranges an answer to over consumption of BE supplements. Understanding the timing and release of supplements used for NBE makes A.D.A.M.E quite feasible.

Pharmacokinetic interactions between herbal medicines and prescribed drugs: focus on drug metabolic enzymes and transporters.
Review article
Meng Q, et al. Curr Drug Metab. 2014.
Show full citation
Abstract
Herbal medicines have been widely used for thousands of years, and now are gaining continued popularity worldwide as a complementary or alternative treatment for a variety of diseases, rehabilitation and health care. Since herbal medicines contain more than one pharmacologically active ingredient and are commonly used with many prescribed drugs, there are potential herb-drug interactions. A variety of reported herb-drug interactions are of pharmacokinetic origin, arising from the effects of herbal medicines on metabolic enzymes and/or transporters. Such an alteration in metabolism or transport can result in changes in absorption, distribution, metabolism, and excretion (e.g., induction or inhibition of metabolic enzymes, and modulation of uptake and efflux transporters), leading to changed pharmacokinetics of the concomitantly prescribed drugs. Pharmacokinetic herb-drug interactions have more clinical significance as pharmacokinetic parameters such as the area under the plasma concentration-time curve (AUC), the maximum plasma concentration (Cmax) or the elimination half-life (t1/2) of the concomitant drug alter. This review summarizes the mechanism underlying herb-drug interactions and the approaches to identify the interactions, and discusses pharmacokinetic interactions of eight widely used herbal medicines (Ginkgo biloba, ginseng, garlic, black cohosh, Echinacea, milk thistle, kava, and St. John's wort) with conventional drugs, using various in vitro, animal in vivo, and clinical studies. The increasing understanding of pharmacokinetic herb-drug interactions will make health care professionals and patients pay more attention to the potential interactions.