16-05-2016, 09:44 PM
Amphiregulin
https://en.wikipedia.org/wiki/Amphiregulin
The protein encoded by this gene is a member of the epidermal growth factor (EGF) family.[1]
It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the Epidermal growth factor receptor (EGFR) to promote the growth of normal epithelial cells
Biological role[edit]
Estradiol and progesterone mostly induce amphiregulin expression to mediate ductal development of the mammary glands.[4][5][6][7][8] Amphiregulin has been found to be essential for mammary ductal development, as evidenced by absence of ductal growth in amphiregulin knockout mice.[7] This is similar to the phenotypes of EGFR and ERα knockout mice, which also show absence of ductal growth
https://en.wikipedia.org/wiki/Progesterone
Progesterone binds extensively to plasma proteins, including albumin (50–54%) and transcortin (43–48%).[28] It has similar affinity for albumin relative to the PR.
Albumin
https://en.wikipedia.org/wiki/Albumin
Serum albumin is the most abundant blood plasma protein and is produced in the liver and forms a large proportion of all plasma protein. The human version is human serum albumin, and it normally constitutes about 50% of human plasma protein.[7]
Serum albumins are important in regulating blood volume by maintaining the oncotic pressure (also known as colloid osmotic pressure) of the blood compartment.[7] They also serve as carriers for molecules of low water solubility this way isolating their hydrophobic nature, including lipid-soluble hormones, bile salts, unconjugated bilirubin, free fatty acids (apoprotein), calcium, ions (transferrin), and some drugs like warfarin, phenobutazone, clofibrate & phenytoin. For this reason, it's sometimes referred as a molecular "taxi". Competition between drugs for albumin binding sites may cause drug interaction by increasing the free fraction of one of the drugs, thereby affecting potency
https://en.wikipedia.org/wiki/Amphiregulin
The protein encoded by this gene is a member of the epidermal growth factor (EGF) family.[1]
It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the Epidermal growth factor receptor (EGFR) to promote the growth of normal epithelial cells
Biological role[edit]
Estradiol and progesterone mostly induce amphiregulin expression to mediate ductal development of the mammary glands.[4][5][6][7][8] Amphiregulin has been found to be essential for mammary ductal development, as evidenced by absence of ductal growth in amphiregulin knockout mice.[7] This is similar to the phenotypes of EGFR and ERα knockout mice, which also show absence of ductal growth
https://en.wikipedia.org/wiki/Progesterone
Progesterone binds extensively to plasma proteins, including albumin (50–54%) and transcortin (43–48%).[28] It has similar affinity for albumin relative to the PR.
Albumin
https://en.wikipedia.org/wiki/Albumin
Serum albumin is the most abundant blood plasma protein and is produced in the liver and forms a large proportion of all plasma protein. The human version is human serum albumin, and it normally constitutes about 50% of human plasma protein.[7]
Serum albumins are important in regulating blood volume by maintaining the oncotic pressure (also known as colloid osmotic pressure) of the blood compartment.[7] They also serve as carriers for molecules of low water solubility this way isolating their hydrophobic nature, including lipid-soluble hormones, bile salts, unconjugated bilirubin, free fatty acids (apoprotein), calcium, ions (transferrin), and some drugs like warfarin, phenobutazone, clofibrate & phenytoin. For this reason, it's sometimes referred as a molecular "taxi". Competition between drugs for albumin binding sites may cause drug interaction by increasing the free fraction of one of the drugs, thereby affecting potency